Overview
The mannose receptor (MR), or CD206, is a transmembrane glycoprotein belonging to the C-type lectin family. It is predominantly expressed on macrophages, dendritic cells, and certain endothelial cells. The receptor recognizes carbohydrate structures, particularly mannose, fucose, and N-acetylglucosamine, which are commonly found on the surface of pathogens like bacteria, fungi, and viruses. MR plays a pivotal role in innate immunity by facilitating pathogen phagocytosis and antigen presentation. It also contributes to immune homeostasis by clearing endogenous glycoproteins and modulating inflammatory responses. Due to its functional versatility, MR is a target for therapeutic interventions and vaccine adjuvants.
Physical and Chemical Properties
The mannose receptor is a large glycoprotein with a molecular weight ranging from 162 to 180 kDa, depending on its glycosylation state. It consists of multiple domains, including a cysteine-rich region, a fibronectin type II domain, and eight C-type lectin-like domains (CTLDs). These domains collectively enable its high-affinity binding to carbohydrate ligands. The receptor is typically isolated in soluble or membrane-bound forms, with solubility dependent on buffer conditions. It is stable in neutral pH but may degrade under extreme conditions. Analytical techniques like SDS-PAGE and ELISA are commonly used to assess its purity and functionality.
Main Applications
In biomedical research, the mannose receptor is studied for its role in pathogen recognition and immune modulation. It is leveraged in vaccine development to enhance antigen uptake by dendritic cells, improving immune responses. MR-targeted drug delivery systems are also explored for treating infections and cancers. Industrially, recombinant MR is used in assays to screen for carbohydrate-binding agents or to study host-pathogen interactions. Its applications extend to diagnostic tools, where it aids in detecting mannosylated biomarkers associated with diseases like tuberculosis and HIV.
Safety and Storage
As a biological reagent, the mannose receptor requires careful handling to maintain stability. It should be stored at -20°C to -80°C in aliquots to avoid repeated freeze-thaw cycles, which can degrade the protein. Lyophilized forms may offer longer shelf life if reconstituted properly. Safety protocols include wearing gloves and lab coats to prevent contamination. While MR is not classified as hazardous, adherence to biosafety level 1 (BSL-1) practices is recommended. Always refer to the supplier’s Material Safety Data Sheet (MSDS) for specific guidelines.
B2B Procurement Guide
When procuring mannose receptor products, prioritize suppliers with proven expertise in glycobiology. Key considerations include purity (≥90% by SDS-PAGE), endotoxin levels (<1 EU/µg), and functional validation (e.g., binding assays). Request a Certificate of Analysis (COA) to confirm specifications. Pricing varies based on quantity, purity, and supplier reputation. Bulk purchases for industrial use may qualify for discounts. For research applications, smaller quantities (e.g., 100 µg) are commonly available. Leading suppliers include R&D Systems, Sigma-Aldrich, and BioLegend.
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