Magnolin
Overview
Magnolin is a naturally occurring lignan isolated from Magnolia species, particularly Magnolia biondii and Magnolia denudata. It is classified as a reference standard in pharmaceutical and biochemical research due to its bioactive properties. As a phytochemical, magnolin has been studied for its potential therapeutic effects, including anti-inflammatory, antioxidant, and neuroprotective activities. Its role in traditional Chinese medicine has also spurred interest in modern pharmacological applications.
Physical and Chemical Properties
Magnolin is a white crystalline solid with a molecular weight of 416.47 g/mol. It is stable under recommended storage conditions but may degrade when exposed to prolonged light or humidity. The compound dissolves readily in polar organic solvents like ethanol and dimethyl sulfoxide (DMSO), making it suitable for laboratory formulations. Its melting point ranges between 120-122°C, and its structural features include a dibenzylbutyrolactone skeleton typical of lignans.
Main Applications
In pharmaceutical research, magnolin serves as a reference standard for quality control in herbal extracts and drug development. Its bioactivity is under investigation for treating inflammatory diseases and neurological disorders. Beyond therapeutics, magnolin is used in academic studies to explore lignan biosynthesis pathways. It is also incorporated into cosmetic formulations for its purported skin-beneficial properties, though clinical evidence remains limited.
Safety and Storage
Magnolin should be handled in compliance with laboratory safety guidelines. Personal protective equipment (PPE), including gloves and goggles, is recommended to prevent skin or eye contact. For long-term stability, store the compound in airtight containers under refrigeration (2-8°C). Avoid repeated freeze-thaw cycles, and ensure the material is protected from light to prevent degradation.
B2B Procurement Guide
When sourcing magnolin, prioritize suppliers with ISO certification or GMP compliance to ensure product integrity. Request certificates of analysis (CoA) detailing purity (≥98% by HPLC) and residual solvent levels. Bulk purchases may qualify for discounts, but validate batch-to-batch consistency. For research purposes, consider small-scale trials before large orders. Lead times vary; plan procurement accordingly, especially for customized purities or formulations.
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