Overview
Liquiritin is a flavonoid glycoside extracted from the roots of licorice (Glycyrrhiza glabra or Glycyrrhiza uralensis). It is a key bioactive compound responsible for many of licorice's therapeutic properties. The compound has gained attention in both traditional and modern medicine for its antioxidant and anti-inflammatory effects. In recent years, liquiritin has been widely adopted in the cosmetic industry for its skin-whitening and anti-aging properties. It inhibits tyrosinase activity, reducing melanin production, and is commonly found in serums, creams, and lotions. Its stability and solubility make it a versatile ingredient for formulations.
Physical and Chemical Properties
Liquiritin is a pale yellow crystalline powder with a molecular weight of 418.39 g/mol. It has a melting point of 212-214 °C and is soluble in water, methanol, and ethanol but less so in non-polar solvents. Its chemical structure includes a flavonoid backbone linked to a glucose moiety, which enhances its bioavailability. The compound exhibits strong UV absorption, making it useful in photoprotective applications. Its stability under moderate temperatures and pH ranges (4-8) allows for incorporation into various formulations without significant degradation. However, exposure to strong acids, bases, or prolonged heat should be avoided.
Main Applications
In pharmaceuticals, liquiritin is used for its hepatoprotective and anti-inflammatory effects, often included in herbal remedies for liver disorders and gastrointestinal inflammation. Clinical studies suggest potential benefits in treating hyperpigmentation and eczema. The cosmetic industry values liquiritin for its skin-brightening properties, often formulating it into whitening creams, sunscreens, and anti-aging products. In food and beverages, it serves as a natural sweetener and flavor enhancer, though its use is less common compared to other licorice extracts like glycyrrhizin.
Safety and Storage
Liquiritin is generally considered safe for topical and oral use in regulated amounts. However, excessive consumption may lead to mild side effects such as nausea or dizziness due to its bioactive nature. Cosmetic formulations typically contain 0.1-2% liquiritin for safe and effective use. Proper storage is essential to maintain stability. The powder should be kept in airtight containers, protected from light and moisture, at temperatures below 25 °C. Bulk suppliers often provide nitrogen-flushed packaging to extend shelf life, which is typically 2-3 years when stored correctly.
B2B Procurement Guide
When sourcing liquiritin, prioritize suppliers with ISO, GMP, or USP certifications to ensure quality and traceability. Key specifications to verify include purity (≥98% by HPLC), residual solvents (meeting ICH guidelines), and heavy metal content (e.g., lead <10 ppm). For large-scale procurement, request batch-specific COAs (Certificates of Analysis) and consider third-party testing for critical applications. Pricing varies based on quantity and purity; bulk purchases (100+ kg) often reduce costs by 10-20%. Lead times can range from 2-6 weeks depending on supplier location and stock availability.
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