Overview
Lanatoside C Reference Standard is a high-purity cardiac glycoside derived from Digitalis lanata. It serves as a critical quality control material in pharmaceutical manufacturing and research laboratories. As a reference standard, it provides the benchmark for identity, purity, and potency testing of related pharmaceutical compounds. The compound is particularly important in the analysis of digoxin and other cardiac glycosides. Pharmaceutical companies and regulatory bodies rely on this reference standard to ensure batch-to-batch consistency and compliance with pharmacopeial standards such as USP and EP.
Physical and Chemical Properties
Lanatoside C is characterized by its crystalline structure and specific optical rotation. The compound shows typical glycoside properties, being moderately polar and exhibiting specific solubility characteristics. Its UV spectrum displays characteristic absorption maxima that aid in identification and quantification. The molecular structure contains a steroidal core with three sugar moieties, contributing to its biological activity and analytical characteristics. The compound is sensitive to heat and light, requiring careful handling and storage to maintain stability.
Main Applications
The primary use of Lanatoside C Reference Standard is in pharmaceutical quality control laboratories. It serves as a system suitability standard for HPLC methods, allowing for the accurate quantification of related compounds in drug substances and products. Research applications include cardiac pharmacology studies, where it's used to investigate the mechanism of action of cardiac glycosides. Additionally, it finds use in method development and validation for regulatory submissions, particularly for drugs containing related cardiac glycosides.
Safety and Storage
As a cardiac glycoside, Lanatoside C requires careful handling due to its potent biological activity. Laboratory personnel should use appropriate personal protective equipment including gloves, lab coats, and eye protection. Work should be conducted in a fume hood when handling powder forms. Proper storage is crucial for maintaining the integrity of the reference standard. The material should be kept in its original container with desiccant, protected from light at controlled refrigeration temperatures (2-8°C). Long-term storage at room temperature may lead to degradation.
B2B Procurement Guide
When procuring Lanatoside C Reference Standard, buyers should prioritize suppliers with documented quality systems. Key considerations include verification of the certificate of analysis, which should detail purity (typically ≥98%), water content, and residual solvents. Pharmaceutical companies should ensure the standard is traceable to recognized pharmacopeias when used for regulatory purposes. Bulk procurement may offer cost advantages, but stability considerations may favor smaller, more frequent purchases to ensure material freshness.
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