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Lactide

Updated: 2026-07-15

Overview

Lactide is a cyclic diester derived from lactic acid, primarily used as a monomer for synthesizing polylactic acid (PLA), a biodegradable polymer. It is categorized into L-lactide, D-lactide, and meso-lactide based on stereochemistry. Its biodegradability and biocompatibility make it valuable in medical and packaging industries. Lactide is synthesized through the condensation of lactic acid molecules, followed by cyclization. The process involves careful control of temperature and catalysts to achieve high purity. The demand for lactide has grown significantly due to the increasing adoption of eco-friendly materials.

Physical and Chemical Properties

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Lactide appears as a white crystalline solid with a molecular weight of 144.13 g/mol. It has a melting point of 95-97 °C and a boiling point of 142 °C at reduced pressure. The compound is soluble in organic solvents like chloroform and acetone but has limited solubility in water. Its cyclic structure and ester linkages contribute to its reactivity, making it suitable for ring-opening polymerization. Lactide is stable under dry conditions but may hydrolyze in the presence of moisture, requiring careful storage.

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Main Applications

Lactide's primary application is in the production of polylactic acid (PLA), a biodegradable plastic used in packaging, textiles, and disposable utensils. PLA's biocompatibility also makes it ideal for medical applications such as sutures, implants, and controlled drug delivery systems. In addition to PLA, lactide is used in adhesives, coatings, and 3D printing resins. Its versatility and eco-friendly properties align with global sustainability trends, driving demand in green manufacturing sectors.

Safety and Storage

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Lactide should be handled with care to avoid inhalation or skin contact, as it may cause irritation. Personal protective equipment (PPE), including gloves and goggles, is recommended during handling. Proper ventilation is essential in workspaces. Storage conditions should be cool, dry, and away from moisture to prevent hydrolysis. Sealed containers with desiccants are ideal. Shelf life can be extended by storing under inert gas, such as nitrogen, to minimize degradation.

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B2B Procurement Guide

When procuring lactide, prioritize suppliers with certifications for purity and consistency, especially for medical or food-contact applications. Key specifications include enantiomeric purity (L-, D-, or meso-lactide) and residual monomer content. Bulk purchases typically offer cost advantages, but ensure storage capacity aligns with usage rates to avoid degradation. Request technical data sheets (TDS) and material safety data sheets (MSDS) to verify compliance with industry standards.

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