L-Valine[3]
Overview
L-Valine is one of the three branched-chain amino acids (BCAAs), alongside leucine and isoleucine. It is classified as an essential amino acid, meaning it cannot be synthesized by the human body and must be obtained through diet or supplementation. L-Valine plays a critical role in muscle metabolism, tissue repair, and nitrogen balance. Industrially, L-Valine is produced through microbial fermentation or chemical synthesis, with fermentation being the more common method due to its cost-effectiveness and environmental benefits. It is widely utilized in pharmaceuticals, sports nutrition, and animal feed formulations to support growth and recovery.
Physical and Chemical Properties
L-Valine is a white crystalline powder with a molecular weight of 117.15 g/mol. It has a density of 1.23 g/cm³ and decomposes at 315°C. The compound is soluble in water but only slightly soluble in ethanol, making it suitable for aqueous formulations. Chemically, L-Valine is hydrophobic and chiral, existing exclusively in the L-configuration in biological systems. Its branched-chain structure contributes to its role in protein folding and stability. These properties make it a valuable component in therapeutic and nutritional applications.
Main Applications
In the pharmaceutical industry, L-Valine is used in intravenous solutions and as a precursor for drug synthesis. It is also a key ingredient in dietary supplements aimed at muscle growth and recovery, particularly for athletes and bodybuilders. In agriculture, L-Valine is added to animal feed to enhance growth performance, especially in poultry and swine. Additionally, it serves as a flavor enhancer in food products, contributing to the umami taste in processed foods and beverages.
Safety and Storage
L-Valine is generally regarded as safe (GRAS) when used as directed. However, prolonged exposure to dust should be avoided to prevent respiratory irritation. Proper storage conditions include a cool, dry environment away from direct sunlight and moisture to maintain stability. For industrial handling, use appropriate personal protective equipment (PPE) such as gloves and masks. Bulk quantities should be stored in sealed containers to prevent contamination and degradation. Always refer to the material safety data sheet (MSDS) for specific guidelines.
B2B Procurement Guide
When purchasing L-Valine in bulk, prioritize suppliers who provide certificates of analysis (COA) to verify purity (typically ≥98%). Compliance with pharmacopeial standards (USP, EP, or BP) is essential for pharmaceutical-grade applications. Consider factors like lead time, packaging options (e.g., 25 kg bags or custom sizes), and logistics support. Pricing varies based on order volume and purity, with discounts often available for large-scale buyers. Establish long-term partnerships with reliable manufacturers to ensure consistent quality and supply.
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