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L-Leucine

Updated: 2026-08-08

Overview

L-Norleucine, chemically known as 2-aminohexanoic acid, is a non-proteinogenic amino acid that is structurally similar to leucine but differs in the placement of its side chain. It is not commonly found in natural proteins but is widely used in scientific research and industrial applications. This amino acid is particularly valued for its role in studying protein structure and function, as well as in the synthesis of peptides and pharmaceuticals. Its unique properties make it a useful tool in biochemistry and molecular biology.

Physical and Chemical Properties

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L-Norleucine is a white crystalline powder with a molecular weight of 131.17 g/mol. It is soluble in water and slightly soluble in ethanol. The compound has a melting point of approximately 300°C, at which it decomposes rather than melts cleanly. As a chiral compound, L-Norleucine exists in two enantiomeric forms, with the L-form being the more commonly used in research and industry. Its solubility and stability under various conditions make it suitable for a range of laboratory and industrial processes.

Main Applications

L-Norleucine is primarily used in biochemical research to study amino acid metabolism and protein synthesis. It serves as a model compound for investigating the effects of amino acid structure on protein folding and stability. In the pharmaceutical industry, L-Norleucine is used as a building block for peptide synthesis and drug development. It is also employed in the production of dietary supplements, where it may be used to mimic the effects of leucine in certain metabolic pathways.

Safety and Storage

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L-Norleucine should be handled with care to avoid inhalation or contact with skin and eyes. Proper personal protective equipment, such as gloves and goggles, should be worn when working with this chemical. Storage conditions are critical to maintaining the stability of L-Norleucine. It should be kept in a cool, dry place, away from light and moisture. Sealed containers are recommended to prevent degradation and contamination.

B2B Procurement Guide

When procuring L-Norleucine, B2B buyers should prioritize suppliers who provide certificates of analysis (CoA) to verify purity and quality. Bulk purchasing can offer cost savings, but it is essential to ensure that storage facilities meet the required conditions. Buyers should also consider the reputation and reliability of suppliers, as well as their ability to provide consistent quality and timely delivery. Comparing prices from multiple suppliers can help in securing the best deal without compromising on quality.

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