Overview
Human Keratin 4 (KRT4) is a type I keratin protein that is primarily expressed in the mucosal epithelium. It is encoded by the KRT4 gene and is part of the keratin family, which provides mechanical support to epithelial cells. KRT4 is essential for maintaining the structural integrity of these cells and plays a role in cell differentiation and wound healing. Research on KRT4 has expanded our understanding of epithelial diseases, including oral lichen planus and other mucosal disorders. Its specific expression pattern makes it a valuable marker for studying epithelial cell biology and pathology.
Physical and Chemical Properties
Human Keratin 4 has a molecular weight of approximately 57 kDa and is typically found as a white to off-white powder. It is soluble in water and common buffers, making it suitable for various laboratory applications. The protein exhibits high stability under standard storage conditions, though prolonged exposure to extreme temperatures should be avoided. KRT4 is characterized by its epithelial cell-specific expression, which distinguishes it from other keratins. This property is leveraged in research to isolate and study epithelial cells, particularly in mucosal tissues.
Main Applications
KRT4 is widely used in medical research, particularly in studies focusing on epithelial cell biology. Its role in maintaining epithelial integrity makes it a key subject in research on mucosal diseases, such as oral lichen planus and esophageal disorders. In addition to research, KRT4 serves as a diagnostic marker for certain epithelial cancers and other pathologies. Its specificity to mucosal epithelium allows for targeted studies and therapeutic development, offering potential advancements in treating epithelial-related conditions.
Safety and Storage
When handling Human Keratin 4, it is recommended to use gloves and avoid inhalation to prevent potential irritation. The protein should be stored at -20°C in a dry environment to maintain its stability and efficacy. Proper labeling and segregation from other chemicals are also advised to prevent contamination. In case of accidental exposure, rinse the affected area with water and seek medical advice if irritation persists. Always refer to the material safety data sheet (MSDS) for detailed safety instructions.
B2B Procurement Guide
When procuring Human Keratin 4, buyers should prioritize suppliers that provide detailed product specifications, including purity levels and source information. Certifications such as ISO or GMP compliance can also indicate product reliability. Price ranges for KRT4 vary depending on purity and supplier, with common ranges between $200 and $500 per mg. Bulk purchases may offer cost savings, but buyers should ensure that storage conditions can accommodate larger quantities without compromising product integrity.
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