Overview
JSH23 is a well-known chemical compound in biomedical research, primarily recognized for its role as a selective inhibitor of the NF-κB signaling pathway. This pathway is crucial in regulating immune responses and inflammation, making JSH23 a valuable tool for studying these biological processes. The compound specifically targets IKKβ, a key kinase in the NF-κB cascade, thereby providing researchers with a precise method to investigate cellular signaling mechanisms. Its application spans academic laboratories and pharmaceutical development, where understanding NF-κB inhibition can lead to potential therapeutic advancements. Due to its specificity and efficacy, JSH23 is often preferred in experiments requiring controlled modulation of inflammatory responses.
Physical and Chemical Properties
JSH23 is a white to off-white powder with a molecular weight of 264.28 g/mol. It is chemically stable under recommended storage conditions but may degrade if exposed to light or moisture. The compound is soluble in dimethyl sulfoxide (DMSO) and slightly soluble in ethanol, which are common solvents used in laboratory settings. Its molecular formula, C16H12N2O2, reflects its organic structure, which includes aromatic rings and functional groups contributing to its inhibitory activity. Researchers should note its solubility profile when preparing stock solutions to ensure accurate dosing in experiments.
Main Applications
JSH23 is predominantly used in research settings to explore the NF-κB pathway's role in inflammation and immune regulation. By inhibiting IKKβ, it helps delineate the pathway's contribution to diseases such as rheumatoid arthritis, cancer, and autoimmune disorders. This makes it a critical tool for preclinical studies aiming to develop novel anti-inflammatory drugs. Additionally, JSH23 is utilized in cell culture experiments to study gene expression and protein interactions influenced by NF-κB. Its specificity allows researchers to isolate the effects of this pathway from other signaling mechanisms, providing clearer insights into cellular behavior under various conditions.
Safety and Storage
Proper handling of JSH23 is essential due to its biochemical activity. Researchers should wear appropriate personal protective equipment, including gloves and lab coats, to prevent skin contact or inhalation. The compound should be stored at -20°C in a tightly sealed container, protected from light and moisture to maintain its stability. In case of accidental exposure, immediate rinsing with water and seeking medical advice is recommended. Disposal should comply with local regulations for chemical waste, ensuring environmental safety. Laboratories should maintain Safety Data Sheets (SDS) for reference in emergency situations.
B2B Procurement Guide
When procuring JSH23, buyers should prioritize suppliers with proven reliability and quality certifications. Key considerations include the compound's purity (typically ≥98% for research use), batch consistency, and documentation such as Certificates of Analysis (CoA). Pricing varies based on quantity and purity, with bulk purchases often offering cost savings. It is advisable to request samples for preliminary testing, especially for large-scale orders. Additionally, verify the supplier's ability to provide technical support and ensure compliance with international shipping regulations for biochemical reagents. Establishing long-term relationships with reputable vendors can streamline procurement processes.
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