Overview
Jervine is a naturally occurring steroidal alkaloid derived from plants in the Veratrum genus, such as Veratrum californicum. It is structurally similar to other alkaloids like cyclopamine and has been extensively studied for its biological effects. Jervine is known for its ability to disrupt cholesterol biosynthesis, making it a compound of interest in pharmacological research. Due to its neurotoxic properties, jervine is also used in toxicology studies to understand its impact on cellular processes. Its role in inhibiting the Hedgehog signaling pathway has further increased its relevance in medical research, particularly in cancer studies.
Physical and Chemical Properties
Jervine is a white to off-white crystalline powder with a molecular weight of 425.61 g/mol. It has a melting point of 243-245 °C and is soluble in organic solvents like ethanol and methanol, though it is only slightly soluble in water. These properties make it suitable for laboratory use where controlled solubility is required. The compound's steroidal backbone contributes to its biological activity, particularly its interaction with cellular receptors. Its stability under standard storage conditions (cool, dry, and protected from light) ensures it remains effective for research purposes over time.
Main Applications
Jervine is primarily used in academic and pharmaceutical research. Its ability to inhibit cholesterol biosynthesis pathways makes it valuable for studying metabolic disorders. Additionally, its neurotoxic effects are leveraged in toxicology to explore mechanisms of neuronal damage. In recent years, jervine has gained attention for its potential role in cancer research, particularly in studies targeting the Hedgehog signaling pathway. This pathway is implicated in several cancers, and jervine's inhibitory effects provide a tool for developing new therapeutic strategies.
Safety and Storage
Due to its toxicity, jervine must be handled with care. Protective equipment such as gloves, goggles, and lab coats are essential when working with this compound. Inhalation or ingestion can lead to severe health effects, including neurological damage. Proper storage is critical to maintaining jervine's stability. It should be kept in a cool, dry place, away from light and moisture. Sealed containers and desiccants are recommended to prevent degradation and ensure the compound remains viable for research use.
B2B Procurement Guide
When procuring jervine for B2B purposes, it is crucial to source from reputable suppliers who provide certificates of analysis (COA) to verify purity. The reference price range is approximately $100-$500 per gram, depending on purity and supplier reliability. Buyers should also consider the intended use of jervine, as different applications may require specific purity levels. Bulk purchases may offer cost savings, but storage capacity and shelf-life considerations should be evaluated to avoid waste.
Related Manufacturers
- 主营：甲基原、钩藤碱、络塞定、丹皮酚、2086-83-1、6836-11-9、鞣花酸、川楝素、黄芩素、苍术素、松脂素、管花苷、熊果酸、苦参碱、6926-08-5、土莫酸、苜蓿素、茯苓酸、柚皮素、3668-14-2、白麻苷、秦皮苷、葛花苷、山奈酚、柚皮苷
- 主营：千金子、大黄素、紫茎女贞苷b、介芬胺、千里光菲灵碱、花青素、甘草系列、水飞蓟系列
- 主营：钩藤碱、丹皮酚、c17h26o10、介芬胺、高良姜、丹参酮、鞣花酸、川楝素、苍术素、芦竹碱、管花苷、苦参碱、土贝母、柚皮素、白麻苷、甜菜碱、紫草素、络石苷、木皂苷、苏木素、甘露糖、番茄碱、青蒿酸、皂苷rg2、芹菜素、紫杉醇
- 主营：ELISA试剂盒、PCR试剂盒、生化试剂盒、脂蛋白、关基因、亲环素、钾通道、列抗体、ntp溶液、蛋白酶、脑蛋白、病毒抗、蛋白质、239抗体、dtt溶液、科研试剂
- 主营：酒渣碱、异常山乙素、芦丁标准品、介芬胺、对照品标准品
- 主营：桤木酮、香附酮、1617-70-5、皂苷rd2、苍术素、2586-96-1、松脂素、管花苷、dl-醉椒、柯诺辛、苜蓿素、夹竹桃、7729-23-9、5928-25-6、化合物、口山酮、3668-14-2、白麻苷、异甘草、木皂苷、脱氧马、刺五加、皂苷rg3、苷甲酯、2292-16-2
- 主营：介芬胺、白僵菌素、薯蓣皂苷
- 主营：桉油精、标准品、薄荷脑、介芬胺、中药对照品、白花前胡丙素、白藜芦醇三甲醚
- 主营：中药对照品
- 主营：标准品、细辛脂素、百两金素、延胡索乙素、桃叶珊瑚苷、脱氢紫堇碱
- 主营：标准品、中药对照品、槲皮万寿菊素、介芬胺、新绿原酸
- 主营：加帽酶、激活剂、甘氨酸、介芬胺、igg抗体、稳定液、玻璃板、试剂盒、脂蛋白、超纯水、激动剂、胆固醇、盐酸盐、因质粒、扩容剂、组化笔、驴抗人、预制胶、驴抗兔、生物驴、草甘膦、重组酶、生物素、曲拉通、去除剂、封闭液
- 主营：Theasinensin A、Theasinensin B、Theasinensin C、介芬胺、花冠木碱、白头翁皂苷D、人参皂苷Ro、矢车菊素-3-半乳糖、竹节参皂苷IVa、林生续断苷I、东当归内酯B、银杏内酯B、欧当归内酯A、70987-96-1、金合欢素、黄芩苷甲酯、樱黄素、台湾泽兰内酯、芫花素、蛇床子素、知母皂苷元、白头翁皂苷B4
- 主营：标准品、人参皂苷、橙皮油素、芥子碱硫氰酸盐
- 主营：对照品、中药多糖、检验检测服务、伪介芬胺、中药研究服务、CMO/CDMO