Overview
Jervine is a steroidal alkaloid primarily extracted from plants of the Veratrum genus, such as Veratrum californicum. It shares structural similarities with cholesterol and is known for its bioactive properties. Historically, it has been used in traditional medicine, though its toxicity limits modern therapeutic applications. Research into jervine has focused on its teratogenic effects, particularly its ability to disrupt embryonic development. This has made it a compound of interest in studies of birth defects and developmental biology. Despite its toxicity, jervine remains a valuable tool in biochemical and pharmacological research.
Physical and Chemical Properties
Jervine is a white to off-white crystalline powder with a molecular weight of 425.61 g/mol. It has a melting point of approximately 245-247°C and is soluble in organic solvents like ethanol and chloroform, though only slightly soluble in water. Its steroidal structure is key to its biological activity. The compound is stable under standard conditions but should be protected from light and moisture to prevent degradation. Its solubility profile makes it suitable for use in various organic solvent-based formulations, though its water insolubility can limit some applications.
Main Applications
Jervine is primarily used in pharmaceutical and biochemical research. Its teratogenic properties have made it a tool for studying developmental disorders and birth defects. It is also investigated for its potential effects on cholesterol metabolism due to its structural similarity to sterols. In traditional medicine, jervine-containing plants were used for their purported therapeutic effects, though modern applications are limited due to toxicity concerns. Today, it is more commonly used in controlled laboratory settings rather than in commercial products.
Safety and Storage
Jervine is toxic if ingested, inhaled, or absorbed through the skin. Proper personal protective equipment (PPE), including gloves and goggles, should be used when handling the compound. It should be stored in a cool, dry place, away from light and moisture to maintain stability. Disposal of jervine should follow local regulations for hazardous chemicals. Due to its teratogenic potential, pregnant women should avoid handling the compound entirely. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.
B2B Procurement Guide
When procuring jervine, buyers should prioritize suppliers who provide high-purity products (≥95%) and can supply certificates of analysis (COA). Prices typically range from $50 to $200 per gram, depending on purity and quantity. Bulk purchases may qualify for discounts. It is essential to verify the compound's purity via HPLC or other analytical methods. Ensure the supplier complies with international safety standards and can provide proper documentation, including SDS. Due to its toxicity, buyers should also confirm that shipping and handling procedures meet regulatory requirements.
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