Overview
Isorhamnetin is a naturally occurring O-methylated flavonol, primarily extracted from sea buckthorn (Hippophae rhamnoides) and other medicinal plants. As a derivative of quercetin, it exhibits enhanced bioavailability and stability due to its methoxy group. It is widely studied for its bioactive properties, including antioxidant, anti-inflammatory, and cardioprotective effects. In traditional medicine, sea buckthorn extracts containing isorhamnetin have been used to treat cardiovascular and gastrointestinal disorders. Modern research focuses on its potential in nutraceuticals and as an adjunct in cancer therapy, owing to its ability to modulate cellular signaling pathways.
Physical and Chemical Properties
Isorhamnetin crystallizes as a yellow powder with a melting point around 307-310°C. Its molecular structure includes a 3'-methoxy group, which distinguishes it from quercetin and contributes to its lipophilicity. The compound is soluble in organic solvents like ethanol and DMSO but has limited water solubility, which influences its formulation in commercial products. Spectroscopic methods such as NMR and HPLC are commonly employed to verify its purity and identity. Stability tests indicate that isorhamnetin degrades under prolonged exposure to UV light or high temperatures, necessitating controlled storage conditions.
Main Applications
Isorhamnetin is primarily used in the nutraceutical industry, where it is incorporated into dietary supplements for its antioxidant benefits. It is also investigated for pharmaceutical applications, including anti-inflammatory drugs and chemopreventive agents, due to its ability to inhibit pro-inflammatory cytokines and oxidative stress. In cosmetics, isorhamnetin is valued for its skin-protective effects against UV-induced damage. Emerging studies explore its role in functional foods and beverages, leveraging its health-promoting properties without altering taste profiles.
Safety and Storage
Isorhamnetin is classified as non-toxic at typical dosages, though high concentrations may cause mild gastrointestinal irritation. Material Safety Data Sheets (MSDS) recommend using personal protective equipment (PPE) such as gloves and masks when handling the powder form to prevent inhalation or contact. For long-term storage, the compound should be kept in airtight containers under inert gas (e.g., nitrogen) at -20°C to prevent oxidation. Bulk procurement should include certificates of analysis (CoA) to ensure compliance with purity standards (≥95%).
B2B Procurement Guide
When sourcing isorhamnetin, prioritize suppliers with GMP or ISO 9001 certification to guarantee quality consistency. Key procurement considerations include batch-to-batch purity (verified via HPLC), solvent residues, and heavy metal content. MOQ (Minimum Order Quantity) typically starts at 10 grams for high-purity grades. Pricing varies based on purity (98%-99.5%) and scale, with bulk purchases (1 kg+) often discounted by 15-30%. Sample testing is advisable to confirm compatibility with downstream formulations, especially for pharmaceutical use.
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