Overview
Isoquinoline (CAS 91-44-1) is a nitrogen-containing heterocycle structurally similar to quinoline. It is a building block for alkaloids and synthetic compounds, with applications spanning pharmaceuticals, dyes, and specialty chemicals. Industrially, it is derived from coal tar or synthesized via Skraup or Bischler-Napieralski reactions. Its aromaticity and basicity make it a versatile intermediate. The compound’s stability and reactivity allow for modifications, enabling diverse downstream products. Due to its niche applications, isoquinoline is typically sourced by B2B buyers in bulk quantities.
Physical and Chemical Properties
Isoquinoline is a colorless to pale yellow liquid at room temperature, with a density of 1.099 g/cm³. It melts at 26-28°C and boils at 242°C. The compound is soluble in most organic solvents (e.g., ethanol, ether) but only slightly soluble in water. Chemically, it behaves as a weak base (pKa ~5.1) and forms stable salts with acids. Its aromatic ring system lends rigidity, influencing reactivity in electrophilic substitutions. The compound’s fluorescence properties are exploited in analytical chemistry and material science.
Main Applications
In pharmaceuticals, isoquinoline serves as a core structure for drugs like papaverine (vasodilator) and antimicrobial agents. It is also a precursor to dyes (e.g., cyanine dyes) and agrochemicals (pesticides). Additional uses include corrosion inhibitors for metals and solvents for resins. Research explores its role in OLEDs and coordination chemistry. The compound’s derivatives are pivotal in alkaloid synthesis, such as berberine and morphine analogs.
Safety and Storage
Isoquinoline is classified as harmful (H302, H312, H315) and requires careful handling. Use gloves, goggles, and respiratory protection in poorly ventilated areas. Avoid contact with skin/eyes and inhalation of vapors. Store in tightly sealed containers away from heat and oxidizers. Recommended storage temperature is below 30°C. In case of spills, absorb with inert material and dispose of as hazardous waste. Follow local regulations for disposal.
B2B Procurement Guide
B2B buyers should prioritize suppliers with ISO 9001 certification and batch-specific COAs (Certificates of Analysis). Key parameters include purity (≥98%), water content (<0.5%), and absence of heavy metals. Packaging options include 25 kg drums or IBCs for bulk orders. Logistics should ensure temperature-controlled transport if required. Sample testing is advised before large purchases. Prices fluctuate with raw material (coal tar) availability; long-term contracts may stabilize costs.
Related Manufacturers
- 主营：异喹啉、聚苯胺、脯氨酸甲酯盐酸盐、苄基三甲基氯化铵
- 主营：硼酸酐、阻聚剂、己二酸、氨基异喹啉、氯化锂、发泡剂、乙二醇、醋酸铜、硅酸钠、正癸醇、新癸酸、环烷油、腰果酚、十二醇、酒石酸、碳酸锂、三甘醇、油菜酸、二甘醇、碳酸钾、甲酸钠、硅酸镁、棕榈油、6-氯嘌呤、微晶石蜡、磷酸一铵
- 主营：肌氨酸钠、硫化锰、V50偶氮二异丁脒盐酸盐、甲氧基异喹啉、腰果酚缩水甘油醚、乙硫氮、二新癸酸二甲基锡、三硫代碳酸钠、PX-4MP、芥酸PKO、四氧化三锰
- 主营：脱模剂、碘酸钾、磷酸镁、异喹啉质量保障、维生素c、维生素b1、维生素b6、维生素d3、二硫化钼、吡啶硫铜、香草香精、芥酸酰胺、乙基纤维素、次氯酸钙、九水硫化钠、EVA乳液、水玻璃、硅酸钠
- 主营：异喹啉制橡胶硫、化工
- 主营：异喹啉制橡胶硫、导电漆、五氧化二钒、漂粉精
- 主营：增稠剂、切削液、胶黏剂、异喹啉制橡胶硫、催化剂、锡酸钠、水杨酸、硫酸锰、铵明矾、聚甘油、肉桂醛、桐油酸、硼酸锌、椰油胺、铜铬黑、清洗剂、泛酸钙、防锈剂、浮选剂、乳酸钙、增感剂、冰晶石、磷酸脲、导热油、碳酸锆、大豆蜡
- 主营：调酸剂、脱溴剂、阻燃剂、异喹啉、胶黏剂、封口蜡、热熔胶、硫酸锂、硫酸锰、聚合物、塑化剂、豆淀粉、快干剂、烟酰胺、灭火剂、柠檬粉、石膏粉、防冻剂、椰油胺、牙膏填、浮选剂、稀释剂、填料剂、去除剂、黄蜂蜡、abs树脂
- 主营：调酸剂、脱溴剂、阻燃剂、异喹啉、有机硫、硫酸锌、封口蜡、热熔胶、掩蔽剂、锂电池、快干剂、烟酰胺、磷酸铁、灭火剂、柠檬粉、石膏粉、磷酸铝、椰油胺、牙膏填、浮选剂、稀释剂、填料剂、去除剂、排除剂、脂肪酶、除磷剂
- 主营：福美钠、漂白粉、次氯酸钠、异喹啉品质保证、强氯精、漂粉精、DOP、DBP、蛋白胨
- 主营：异喹啉磺酸原料、麦芽糖酸、苯氧基环磷腈、甲巯基四氮唑
- 主营：异丙醇、二甲胺、二甲苯、四氢异喹啉、苯基氯、二甘醇、石炭酸、乙二醇、丙烯酸、仲丁醇、水溶液、羟基苯、红铅丹、氨基苯、安息油、环己醇、正丁醇、84消毒液、单乙醇胺、医用酒精、液状石蜡、邻甲苯胺、杀菌消毒、乙基三胺、出口酒精、乙烯基苯
- 主营：异喹啉羧酸现货供应、分析纯试剂
- 主营：异喹啉异喹啉价格香料、化工原料、工业添加剂、进口原料
- 主营：山梨酸钾、羟基嘧啶、吡唑啉酮、异喹啉磺酸、清凉茶酸、山梨酸钙、磺酸苯基、叔丁基锂、双乙烯酮、基氨基锂、氯乙酰氯、三正丁基、四羟甲基、乙酰苯胺、甲基苯基、氯羟吡啶、硫酸磷脲