Isomangiferin

Updated: 2026-09-15

Overview

Isomangiferin is a naturally occurring xanthonoid compound, structurally similar to mangiferin. It is primarily extracted from plants such as mangosteen (Garcinia mangostana) and Anemarrhena asphodeloides rhizome. The compound has garnered attention for its bioactive properties, including antioxidant, anti-inflammatory, and potential neuroprotective effects. In traditional medicine, extracts containing isomangiferin have been used for their therapeutic benefits. Modern research explores its applications in pharmaceuticals and nutraceuticals, particularly for managing oxidative stress and inflammatory conditions. Its role in cosmetic formulations is also under investigation due to its skin-protective qualities.

Physical and Chemical Properties

Isomangiferin is a pale yellow crystalline powder with a molecular weight of 422.34 g/mol. It has a melting point of approximately 220-225°C and is soluble in polar organic solvents like methanol and ethanol, though it exhibits limited solubility in water. The compound's stability is influenced by environmental factors such as light and moisture, necessitating proper storage conditions. Chemically, isomangiferin belongs to the xanthone class, characterized by a distinctive tricyclic aromatic structure. This framework contributes to its ability to scavenge free radicals and modulate inflammatory pathways. Analytical methods like HPLC and NMR are commonly employed to verify its purity and structural integrity.

Main Applications

Isomangiferin's primary applications lie in the pharmaceutical and nutraceutical industries. Its antioxidant properties make it a candidate for formulations targeting oxidative stress-related disorders, such as cardiovascular diseases and neurodegenerative conditions. Research also highlights its anti-inflammatory potential, suggesting utility in treating chronic inflammatory diseases. In the cosmetic sector, isomangiferin is explored for its ability to protect skin from UV-induced damage and aging. Additionally, it is incorporated into dietary supplements aimed at enhancing immune function and reducing inflammation. The compound's versatility underscores its value across multiple health and wellness domains.

Safety and Storage

Isomangiferin should be handled with standard laboratory precautions, including the use of gloves and eye protection to avoid direct contact. While it is generally considered safe at typical usage levels, prolonged exposure or high doses may require further toxicological evaluation. Storage recommendations include keeping the compound in a cool, dry environment, protected from light and moisture to prevent degradation. Sealed containers with desiccants are advisable for long-term preservation. Suppliers often provide stability data and material safety data sheets (MSDS) for reference.

B2B Procurement Guide

When procuring isomangiferin, B2B buyers should prioritize purity verification, typically through HPLC analysis (≥98% purity is common for research-grade material). Supplier certifications, such as ISO or GMP compliance, are critical for ensuring quality and consistency. Batch-to-batch variability can affect performance in end products, so requesting certificates of analysis (CoA) and samples for testing is advisable. Pricing varies based on purity, quantity, and supplier reputation, with bulk purchases often attracting discounts. Lead times and shipping conditions (e.g., temperature control) should also be confirmed.