Overview
Isopilocarpine is an alkaloid found in the leaves of the Pilocarpus microphyllus plant, commonly known as jaborandi. It is structurally related to pilocarpine, a compound widely used in the treatment of glaucoma and dry mouth. While less studied than pilocarpine, isopilocarpine has shown potential in pharmaceutical research due to its similar cholinergic properties. This compound is of interest in the development of new therapeutic agents, particularly in ophthalmology and neurology. Its natural origin and bioactivity make it a candidate for further investigation in drug discovery and development.
Physical and Chemical Properties
Isopilocarpine is a white to off-white crystalline powder with a molecular weight of 208.26 g/mol. It is soluble in water, ethanol, and chloroform, which makes it versatile for various formulations. The melting point is approximately 90-95°C, indicating moderate thermal stability. The compound's cholinergic activity is due to its interaction with muscarinic receptors, similar to pilocarpine. This property is key to its potential applications in medicine. However, its exact pharmacological profile and potency compared to pilocarpine require further research.
Main Applications
The primary application of isopilocarpine is in pharmaceutical research, where it is studied for its potential use in treating conditions like glaucoma and Sjögren's syndrome. Its cholinergic effects may also be explored for neurological disorders, though clinical evidence is limited. In addition to therapeutic uses, isopilocarpine serves as a reference compound in biochemical assays to study receptor interactions. Its natural origin and structural similarity to pilocarpine make it a valuable tool for comparative studies in drug development.
Safety and Storage
Isopilocarpine should be handled with care, as it may cause irritation to the skin, eyes, and respiratory system. Proper personal protective equipment (PPE), such as gloves and goggles, is recommended when working with this compound. Storage conditions are critical to maintaining its stability. It should be kept in a cool, dry place, protected from light and moisture. Properly sealed containers and controlled environments are essential to prevent degradation over time.
B2B Procurement Guide
When procuring isopilocarpine, B2B buyers should prioritize suppliers who provide a Certificate of Analysis (COA) to verify purity and quality. Due to its niche application, availability may vary, so establishing long-term relationships with reliable suppliers is advisable. Pricing is typically influenced by purity levels and order volume. Buyers should request samples for testing before large-scale purchases. Additionally, ensure compliance with local regulations regarding the import and use of alkaloids in pharmaceutical research.
Related Manufacturers
- 主营：丹皮酚、c17h26o10、高良姜、钩藤碱、芦竹碱、苦参碱、甜菜碱、番茄碱、丹参酮、鞣花酸、川楝素、苍术素、管花苷、土贝母、柚皮素、白麻苷、紫草素、络石苷、木皂苷、苏木素、甘露糖、青蒿酸、皂苷rg2、芹菜素、紫杉醇
- 主营：中药对照品
- 主营：酒渣碱、异常山乙素、芦丁标准品、对照品标准品
- 主营：对照品、标准品、当归酸酐、异斑点沸林草碱、佛手柑内酯、新当归内酯、补骨脂甲素、补骨脂乙素、羟基芍药苷、阿魏酸松柏酯、水合氧化前胡素、豆甾醇葡萄糖苷
- 主营：桤木酮、香附酮、1617-70-5、异甘草、皂苷rd2、苍术素、2586-96-1、松脂素、管花苷、dl-醉椒、柯诺辛、苜蓿素、夹竹桃、7729-23-9、5928-25-6、化合物、口山酮、3668-14-2、白麻苷、木皂苷、脱氧马、刺五加、皂苷rg3、苷甲酯、2292-16-2
- 主营：甲基原、络塞定、丹皮酚、钩藤碱、苦参碱、2086-83-1、6836-11-9、鞣花酸、川楝素、黄芩素、苍术素、松脂素、管花苷、熊果酸、6926-08-5、土莫酸、苜蓿素、茯苓酸、柚皮素、3668-14-2、白麻苷、秦皮苷、葛花苷、山奈酚、柚皮苷