Overview
Isoliquiritigenin is a naturally occurring flavonoid derived from licorice root (Glycyrrhiza species). It belongs to the chalcone subclass of flavonoids and is recognized for its bioactive properties. The compound has been extensively studied for its potential health benefits, including antioxidant, anti-inflammatory, and chemopreventive effects. In traditional medicine, licorice extracts containing isoliquiritigenin have been used for centuries. Modern research has isolated this compound to explore its mechanisms and applications in pharmaceuticals and nutraceuticals. Its ability to modulate cellular pathways makes it a candidate for therapeutic development.
Physical and Chemical Properties
Isoliquiritigenin is a yellow crystalline powder with a molecular weight of 256.25 g/mol. It is characterized by its chalcone structure, featuring two aromatic rings connected by a three-carbon α,β-unsaturated carbonyl system. This structure contributes to its reactivity and biological activity. The compound is stable under recommended storage conditions but may degrade when exposed to prolonged light or moisture. Its solubility in organic solvents like ethanol and DMSO makes it suitable for laboratory and industrial applications, while its limited water solubility can be addressed with formulation techniques.
Main Applications
Isoliquiritigenin is primarily used in the pharmaceutical industry for drug development, particularly in cancer research due to its potential to inhibit tumor growth. It is also incorporated into anti-inflammatory and antioxidant formulations. In cosmetics, isoliquiritigenin is valued for its skin-brightening and anti-aging properties. It is found in serums, creams, and lotions aimed at reducing oxidative stress and inflammation. Additionally, the compound is used in dietary supplements to promote overall health, often marketed for its immune-boosting and detoxifying effects.
Safety and Storage
Isoliquiritigenin should be handled with care, using appropriate personal protective equipment (PPE) such as gloves and goggles. While it is generally considered safe at low concentrations, high doses may cause irritation or adverse effects. Storage requires a cool, dry environment, ideally at temperatures below 25°C, and protection from light and moisture to prevent degradation. Properly sealed containers are essential to maintain purity and efficacy. Bulk quantities should be stored in inert atmospheres if long-term stability is required.
B2B Procurement Guide
When sourcing isoliquiritigenin, B2B buyers should prioritize suppliers with verified certifications (e.g., ISO, GMP) to ensure quality and consistency. Key procurement considerations include purity levels (typically 95%-98% by HPLC), batch-to-batch variability, and compliance with regulatory standards (e.g., USP, EP). Pricing varies based on purity, quantity, and supplier reputation. Bulk purchases may offer cost advantages, but buyers should request samples for quality testing before large-scale orders. Reliable suppliers often provide technical support and documentation, such as MSDS and COA, to facilitate informed purchasing decisions.
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