Overview
Isoflavone reference standard is a high-purity chemical compound primarily used in pharmaceutical and research laboratories for quality control and analytical purposes. It serves as a benchmark in chromatographic techniques such as HPLC and LC-MS to ensure the accuracy and consistency of test results. The compound is derived from natural sources or synthesized to meet stringent purity requirements, making it indispensable in drug development and regulatory compliance. Reference standards like isoflavone are critical for validating analytical methods and calibrating instruments. They help in identifying and quantifying active pharmaceutical ingredients (APIs) and impurities in drug formulations. The use of certified reference standards ensures that laboratories adhere to Good Laboratory Practices (GLP) and meet international regulatory standards.
Physical and Chemical Properties
Isoflavone reference standard is characterized by its white to off-white crystalline powder form. It has a molecular formula of C15H10O2 and a molecular weight of 222.24 g/mol. The compound is stable under recommended storage conditions but may degrade if exposed to moisture, heat, or light. Its melting point ranges between 150-155°C, and it is soluble in common organic solvents like methanol and ethanol. The solubility of isoflavone in water is limited, which is a consideration when preparing solutions for analytical purposes. Its high purity (>98%) ensures minimal interference in analytical tests, making it a reliable choice for precise measurements. The compound's stability and solubility profile are key factors in its widespread use in pharmaceutical quality control.
Main Applications
The primary application of isoflavone reference standard is in the pharmaceutical industry, where it is used to validate analytical methods and ensure the quality of drug products. It is commonly employed in high-performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS) to quantify isoflavones in herbal extracts and pharmaceutical formulations. In addition to pharmaceuticals, isoflavone reference standards are used in research laboratories to study the biological effects of isoflavones, such as their antioxidant and estrogenic properties. They are also utilized in the food and nutraceutical industries to standardize the content of isoflavones in dietary supplements and functional foods. The versatility of this reference standard makes it a valuable tool across multiple scientific disciplines.
Safety and Storage
Proper handling and storage of isoflavone reference standard are essential to maintain its integrity and ensure safety in the laboratory. The compound should be stored in a cool, dry place, away from direct sunlight and moisture. The container must be tightly sealed to prevent contamination and degradation. Safety precautions include wearing appropriate personal protective equipment (PPE) such as gloves, lab coats, and safety goggles. Inhalation, ingestion, or skin contact should be avoided, as the compound may cause irritation. In case of exposure, rinse thoroughly with water and seek medical attention if necessary. Always work in a well-ventilated area or under a fume hood to minimize the risk of inhalation.
B2B Procurement Guide
When procuring isoflavone reference standard, it is crucial to verify the purity and certification provided by the supplier. Look for suppliers who comply with international standards such as the United States Pharmacopeia (USP) or European Pharmacopoeia (EP). The certificate of analysis (CoA) should detail the purity, impurities, and testing methods used. Consider the supplier's reputation, lead times, and packaging options. Bulk purchases may offer cost savings, but ensure that the storage conditions during transit and upon receipt are adequate to maintain the compound's stability. For reference, the price typically ranges from $50 to $200 per gram, depending on purity and supplier. Always confirm regulatory compliance to avoid delays in your analytical workflows.
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