Overview
Isobenzofuran is a bicyclic heteroaromatic compound consisting of a fused benzene and furan ring. It is a reactive intermediate widely used in organic synthesis, particularly in the production of pharmaceuticals and specialty chemicals. Due to its diene character, isobenzofuran participates in cycloaddition reactions like the Diels-Alder reaction, making it valuable for constructing complex molecular frameworks. Commercial availability is typically limited to small quantities for research purposes.
Physical and Chemical Properties
Isobenzofuran is a volatile, low-melting solid or liquid at room temperature, depending on purity. Its conjugated π-electron system gives it characteristic UV absorption at ~290 nm. The compound exhibits high reactivity due to its strained structure and electron-rich furan ring. It polymerizes readily upon exposure to air or light, necessitating stabilization with antioxidants like BHT during storage. Its solubility profile favors organic solvents, with limited stability in aqueous environments.
Main Applications
In pharmaceutical synthesis, isobenzofuran serves as a precursor to anticoagulants, antipsychotics, and other bioactive molecules. Its ability to form adducts with electron-deficient dienophiles enables efficient construction of polycyclic structures. The agrochemical industry utilizes derivatives for crop protection agents. Additionally, it finds niche applications in materials science for creating conjugated polymers with optoelectronic properties.
Safety and Storage
As a flammable and reactive compound, isobenzofuran requires careful handling under inert atmosphere (nitrogen/argon). Storage at 2-8°C in amber glass with oxygen scavengers prolongs shelf life. Personal protective equipment (PPE) including nitrile gloves and splash goggles is mandatory. Spills should be absorbed with inert material and disposed as hazardous waste. Never expose to strong oxidizers due to fire/explosion risk.
B2B Procurement Guide
Industrial buyers should prioritize suppliers offering stabilized formulations with certificates of analysis (CoA). Bulk purchases (>1kg) typically require custom synthesis arrangements. Key procurement considerations include: batch-to-batch consistency, HPLC purity verification, and supplier capability for hazardous material transportation. Lead times may extend to 4-6 weeks for customized orders. Consider establishing long-term contracts with qualified producers to ensure supply chain stability.
Related Manufacturers
- 主营：叔碳酸、十八醛、溶菌酶、异苯并呋喃酮、海藻糖、癸二醇、氨基丙基、氢路噻嗪、邻苯二甲、乙基碳二、羟基癸酸、正十七烷、谷胱甘肽、烷二甲醇、松果体素、vc磷酸酯镁、2-甲基丁醛、朱栾倍半萜、丁烷四乙酸、表面活性剂、癸烷撑二醇、缩水甘油邻、10-羟基羊蜡酸、氢氯噻嗪杂质、盐酸邻菲罗啉、壳聚糖季铵盐
- 主营：有机原料、中间体、香精香料、催化剂、有机硅、表面活性剂
- 主营：DMF、DMAC、二丙酮醇、四氢呋喃、四甲基胍、马来酸酐、丙二醇、乙二醇、甲酸、甲醇、十二醇、柠檬酸、己二醇、甘油、碳酸丙烯酯、吐温、无水氯化钙、乙酸乙酯、氢氧化钠、二乙醇胺、司盘、过硫酸钠、氧化钙、氯化钾
- 主营：环戊酮、甲酸镍、阻燃剂、草酸镧、钼酸铵、催化剂、钒酸铋、溴氨酸、硝酸锆、碳酸镧、白僵菌、磷酸铁、钨酸酐、氟化镧、视黄醇、叔丁醇、杀螨剂、杀虫剂、醋酸钬、抗粘剂、氟化镥、肟菌酯、氢化钠、氯铂酸、氟化镁
- 主营：化学品、香精香料、试剂、溴异苯并呋喃、中间体、有机硅、橡胶树脂、催化剂、纳米材料
- 主营：杜仲素、对位酯、丙烯酸酯、二氧化硫脲、乙基麦芽酚、饲料添加剂、油酸基硬脂酸、二苯基硅二醇
- 主营：透析袋、移液器、SIGMA、二苯基异苯并呋喃105481、赛默飞、爱思进、吸头/枪头、离心管、巴氏吸管、保存管、封板膜、细胞爬片、滤器、ELISA试剂盒
- 主营：4-对二氯苄、2-甲基咪唑、咪唑、对甲苯磺酸、防染盐S、黄血盐钾、聚六亚甲基胍盐酸盐、红丹粉、黄丹粉、巴豆酸、巴豆醛、二氢茉莉酮酸甲酯、对苯二甲酸、氢氧化钡、三硫代碳酸钠、丙酮肟、九水硫化钠、碱式碳酸铅、乙醛肟、甲基三乙氧基硅烷、氟化钾、氟化钠、乙二胺四乙酸二钾、醋酸铅
- 主营：全氟三丁胺、氢化镁、碳纳米管导电浆料、异苯并呋喃酮、羟基磷灰石、311-89-7、提取物、树脂、硅烷、萃取剂
- 主营：扩链剂、咪唑系列、阻燃剂、异苯并呋、离子液体、催化剂、乙酰丙酮系列、固化剂系列
- 主营：氯化氢乙醇、二苯基硅二醇、甲基磺酸铋、二苯基异苯并呋喃、阻燃剂DDP、萃取剂、HTPB、防老剂
- 主营：防老剂、香精香料、乳化剂、二苯基异苯并呋喃、壳聚糖
- 主营：阻燃剂、乙酸镍、乙酸镝、异苯并呋喃二酮厂家、硫酸锂、硫酸锶、溴氨酸、香茅醇、肌氨酸、锂电池、四氢萘、磷酸铬、碳酸镁、碳酸镍、防冻剂、磷酸铝、叔丁醇、氟苯基、浮选剂、稀释剂、羟乙基、去除剂、庚二酸、除磷剂、十八烯、蛋白酶
- 主营：乙酸龙脑酯、聚苯乙烯磺酸钠、乙基黄原酸钾、异苯并呋喃酮、2-十一酮
- 主营：甘氨酸、甘氨酰、阻燃剂、异丁酯、甲醇钠、蒽甲酯、十八酸、溴壬烷、肉桂醇、葱油醇、肉桂醛、赖氨酸、叔丁醇、多佐胺、醛试剂、醇酯-12、乙氧基、脯氨酸、牛胆粉、癸酸酯、化合物、氟苯基、敏材料、氨酰胺、扁油酸