Overview
Inulicin is a bioactive sesquiterpene lactone primarily extracted from Inula helenium (elecampane) roots. This secondary plant metabolite has been used in traditional European and Asian medicine for centuries, particularly for respiratory ailments. Modern research focuses on its pharmacological potential, including antitumor and immunomodulatory effects. The compound's unique γ-lactone structure contributes to its biological activity. Industrially, it's classified as a high-value fine chemical, with most commercial production occurring through plant extraction rather than synthesis due to its complex stereochemistry.
Physical and Chemical Properties
Inulicin forms orthorhombic crystals with characteristic bitter taste. Its low water solubility but good organic solvent compatibility makes it suitable for ethanol-based formulations. The lactone ring is stable under acidic conditions but may hydrolyze in strong bases. Spectroscopic properties include UV absorption maxima at 220 nm and 280 nm. The compound demonstrates optical activity with [α]D20 = +68° (c=1, CHCl3). Thermal analysis shows decomposition above 200°C, requiring careful processing in industrial applications.
Main Applications
Pharmaceutical companies utilize Inulicin as a precursor for anti-inflammatory drugs and investigational cancer therapies. Its ability to inhibit NF-κB signaling makes it valuable in autoimmune disease research. Traditional medicine applications include expectorant formulations and digestive aids. In agriculture, it serves as a natural antifungal agent for crop protection. Emerging applications include functional food additives and cosmetic preservatives, though these require further toxicological evaluation. The compound's chiral structure also makes it useful as a resolving agent in asymmetric synthesis.
Safety and Storage
As a moderately toxic compound, Inulicin requires proper ventilation and chemical-resistant gloves during handling. The dust may cause respiratory irritation, necessitating P2-grade respirators in powder processing. Spills should be contained with inert absorbents. Long-term storage stability requires protection from humidity and oxidation. Argon-blanketed containers are recommended for high-purity grades. Shelf life typically exceeds 3 years when stored below 8°C, with periodic purity checks advised for critical applications.
B2B Procurement Guide
Industrial buyers should prioritize suppliers providing batch-specific NMR and HPLC data, with particular attention to isomeric purity. MOQ typically starts at 1 kg for pharmaceutical-grade material, with lead times of 2-4 weeks for custom purifications. Quality indicators include white crystalline appearance (yellowing suggests oxidation) and >97% chromatographic purity. Consider suppliers with ISO 9001 certification and proper cold chain logistics. For research quantities, 100mg vials are commonly available from specialty chemical distributors at premium pricing.
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