Overview
Indirubin is a naturally occurring compound derived from indigo plants, such as Indigofera tinctoria and Isatis indigotica. It is a red isomer of indigo and has been used for centuries in traditional Chinese medicine, particularly for treating chronic myelogenous leukemia and inflammatory diseases. In modern times, indirubin has gained attention for its potential therapeutic applications, including anti-cancer and anti-inflammatory properties. Research is ongoing to explore its mechanisms of action and efficacy in various medical conditions.
Physical and Chemical Properties
Indirubin appears as a dark red crystalline powder with a melting point of 356-358°C. It is poorly soluble in water but dissolves well in dimethyl sulfoxide (DMSO) and slightly in ethanol. Its molecular structure includes two nitrogen atoms, contributing to its biological activity. The compound is stable under normal storage conditions but should be protected from light and moisture to prevent degradation. Its distinctive color makes it useful as a dye, while its chemical properties enable its use in pharmaceutical formulations.
Main Applications
Indirubin is primarily used in traditional Chinese medicine, where it is valued for its ability to treat blood disorders and inflammatory conditions. It is a key component in formulations like Dang Gui Long Hui Wan, which is used for chronic myelogenous leukemia. In modern pharmaceuticals, indirubin is being studied for its potential to inhibit cancer cell proliferation and reduce inflammation. It is also used in laboratory research as a reference compound for studying kinase inhibitors and other biological pathways.
Safety and Storage
Indirubin should be handled with care, as it may cause skin and eye irritation. Proper personal protective equipment, such as gloves and goggles, should be worn when handling the compound. It should be stored in a cool, dry place away from direct sunlight and moisture to maintain its stability. In case of accidental exposure, rinse affected areas with plenty of water and seek medical advice if necessary. Always follow safety data sheet (SDS) guidelines and local regulations for chemical handling and disposal.
B2B Procurement Guide
When procuring indirubin for commercial or research purposes, it is essential to verify the supplier's credentials and request certificates of analysis (CoA) to confirm purity and quality. Prices can vary significantly based on purity and supplier, ranging from approximately $50 to $200 per gram. Bulk purchases may qualify for discounts, but buyers should ensure proper storage conditions during transit. Consider working with suppliers who specialize in pharmaceutical or botanical extracts to ensure consistent quality and reliable supply chains.
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