Overview
Indane, chemically known as 2,3-dihydro-1H-indene, is a bicyclic hydrocarbon consisting of a benzene ring fused with a cyclopentane ring. It is a colorless liquid with a characteristic aromatic odor. As a versatile intermediate, indane plays a significant role in organic synthesis, particularly in the production of pharmaceuticals, agrochemicals, and fragrances. Its structure makes it a valuable building block for more complex molecules. The compound is commercially available and typically synthesized through catalytic hydrogenation of indene. Industrial applications leverage its stability and reactivity in various chemical processes.
Physical and Chemical Properties
Indane is a volatile, flammable liquid with a density slightly lower than water (0.963 g/cm³). It has a melting point of -51°C and boils at 176-177°C, making it suitable for reactions requiring moderate temperatures. The compound is insoluble in water but readily dissolves in common organic solvents such as ethanol, ether, and benzene. Chemically, indane exhibits typical hydrocarbon behavior, participating in reactions like halogenation, sulfonation, and Friedel-Crafts alkylation. Its stability under normal conditions and predictable reactivity profile make it a preferred choice in synthetic chemistry.
Main Applications
Indane is primarily used as an intermediate in the synthesis of pharmaceuticals, including nonsteroidal anti-inflammatory drugs (NSAIDs) and antihistamines. Its derivatives are also employed in the production of perfumes and flavoring agents due to their pleasant aromatic properties. In agrochemicals, indane serves as a precursor for pesticides and herbicides. Additionally, it finds use in polymer chemistry as a modifier to enhance material properties. The compound's versatility ensures steady demand across multiple industries.
Safety and Storage
As a flammable liquid, indane requires careful handling to prevent fire hazards. It should be stored in tightly sealed containers in a cool, dry, well-ventilated area, away from heat sources and open flames. Proper grounding is essential to avoid static discharge during transfer. Personal protective equipment (PPE), including gloves and safety goggles, is recommended when handling indane. In case of skin contact, wash immediately with soap and water. Eye exposure necessitates rinsing with plenty of water for at least 15 minutes. Always refer to the material safety data sheet (MSDS) for detailed safety protocols.
B2B Procurement Guide
When procuring indane, prioritize suppliers with certifications such as ISO or GMP to ensure product quality and consistency. Key specifications to verify include purity (typically ≥98%), moisture content, and absence of impurities. Bulk purchases may offer cost advantages, but ensure proper storage facilities are available. Request samples for testing before large-scale orders, especially for critical applications like pharmaceuticals. Establish long-term contracts with reliable suppliers to secure stable pricing and supply. Monitor market trends, as prices can fluctuate based on raw material availability and demand.
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