Overview
ICG-PEG-FA is a multifunctional conjugate integrating Indocyanine Green (ICG), polyethylene glycol (PEG), and folic acid (FA). ICG provides near-infrared fluorescence for imaging, PEG enhances solubility and biocompatibility, and FA enables targeted delivery to folate receptor-overexpressing cells (e.g., cancer cells). This compound is widely used in biomedical research, particularly for tumor detection and drug delivery systems. Its modular design allows customization of PEG chain lengths to optimize pharmacokinetics. Researchers must select specifications based on intended applications, such as in vivo imaging or therapeutic agent conjugation.
Physical and Chemical Properties
ICG-PEG-FA exhibits strong absorption and emission in the near-infrared range (700–850 nm), making it ideal for deep-tissue imaging. The PEG spacer improves stability and reduces immunogenicity, while the FA moiety binds selectively to folate receptors. The conjugate’s solubility depends on the PEG chain length; shorter chains (e.g., PEG2000) offer better water solubility, whereas longer chains (e.g., PEG5000) may require organic solvents. Storage at -20°C in dark conditions is critical to prevent photodegradation of ICG and hydrolysis of the FA linkage.
Main Applications
ICG-PEG-FA is primarily used in oncology for real-time tumor imaging during surgery or endoscopy. Its fluorescence guides resection margins, reducing recurrence risks. Additionally, it serves as a carrier for targeted drug delivery, conjugating chemotherapeutics or nanoparticles to FA for receptor-mediated uptake. In research, it aids in studying folate receptor dynamics and biodistribution. Emerging applications include photothermal therapy, where ICG’s light absorption generates localized heat to destroy cancer cells. Compatibility with MRI or CT contrast agents further expands its diagnostic utility.
Safety and Storage
While ICG-PEG-FA is generally biocompatible, precautions are necessary due to its light-sensitive and hygroscopic nature. Use amber vials and desiccants during storage. Handle with gloves and avoid direct skin/eye contact. For in vivo use, conduct preliminary toxicity assays, as ICG may cause allergic reactions in rare cases. Sterile filtration is recommended for injectable formulations. Dispose of waste according to local regulations for organic dyes and PEG derivatives.
B2B Procurement Guide
When procuring ICG-PEG-FA, prioritize suppliers with detailed analytical certificates (HPLC, MS, NMR). Key parameters include PEG molecular weight (e.g., 2kDa, 5kDa), ICG/FA conjugation efficiency (>90%), and endotoxin levels (<0.1 EU/mg) for clinical-grade material. Bulk orders (100+ mg) may qualify for discounts, but verify scalability of synthesis. Consider custom modifications (e.g., maleimide-PEG for thiol coupling) if needed. Lead times vary; specialty conjugates may require 4–8 weeks for synthesis and QC.
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