Overview
Ibuprofen, chemically known as 2-(4-isobutylphenyl)propionic acid, is a widely recognized NSAID first developed in the 1960s. It is commonly used to treat mild to moderate pain, inflammation, and fever. Its mechanism of action involves inhibiting cyclooxygenase enzymes (COX-1 and COX-2), which are responsible for prostaglandin synthesis. Due to its efficacy and safety profile, ibuprofen is available over-the-counter in many countries. It is formulated into tablets, capsules, gels, and suspensions, making it versatile for various patient needs. The drug is also a staple in hospitals and clinics for postoperative pain management.
Physical and Chemical Properties
Ibuprofen is a white crystalline powder with a characteristic faint odor. It has a molecular weight of 206.29 g/mol and a melting point of 75-77 °C. The compound is lipophilic, contributing to its ability to penetrate cell membranes and exert its effects. Its solubility profile shows higher dissolution in organic solvents like ethanol and acetone but limited solubility in water. This property influences its formulation into different delivery systems, such as oral tablets or topical gels. The density of ibuprofen is approximately 1.03 g/cm³, and it decomposes at higher temperatures, releasing carbon monoxide and dioxide.
Main Applications
Ibuprofen is primarily used for its analgesic, antipyretic, and anti-inflammatory effects. It is effective in treating conditions like headaches, dental pain, menstrual cramps, and musculoskeletal injuries. In chronic settings, it helps manage symptoms of rheumatoid arthritis and osteoarthritis. The drug is also employed in pediatric care for fever reduction, though dosing must be carefully calibrated. Beyond human medicine, ibuprofen is sometimes used in veterinary applications. Its versatility and low cost make it a preferred choice in both developed and developing healthcare systems.
Safety and Storage
While ibuprofen is generally safe for short-term use, prolonged consumption can lead to gastrointestinal ulcers, kidney dysfunction, or cardiovascular risks. Patients with pre-existing conditions like asthma or liver disease should use it cautiously. Proper storage involves keeping the compound in a tightly sealed container, away from light and moisture, at room temperature. Bulk pharmaceutical-grade ibuprofen must comply with regulatory standards (e.g., USP, EP) to ensure purity and efficacy. Disposal should follow local guidelines to prevent environmental contamination.
B2B Procurement Guide
B2B buyers should prioritize suppliers with certifications like GMP or ISO to guarantee product quality. Key considerations include purity levels (typically 98-99.5%), packaging options (e.g., 25 kg drums), and batch testing reports. Prices vary based on order volume and supplier location, with bulk purchases often attracting discounts. Logistics planning is crucial, as ibuprofen is sensitive to temperature fluctuations during transit. Buyers are advised to request samples and conduct third-party lab tests before large-scale procurement.
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