Overview
Hydroxypropyl Methylcellulose Phthalate (HPMCP) is a semisynthetic polymer derived from cellulose, modified with hydroxypropyl and phthalate groups. It is widely used in the pharmaceutical industry due to its pH-sensitive solubility, making it ideal for enteric coatings that protect drugs from gastric acid. HPMCP was developed as an alternative to traditional enteric materials like shellac, offering improved consistency and compatibility with modern drug formulations. Its ability to dissolve in intestinal fluids (pH ≥5.5) ensures targeted drug release, enhancing bioavailability and reducing gastric irritation.
Physical and Chemical Properties
HPMCP is a white to off-white powder with no discernible odor. Its solubility profile is its most critical property: insoluble in water and acidic environments but readily soluble in alkaline pH (≥5.5) and organic solvents like acetone. This pH-dependent behavior is due to the ionization of phthalate groups. The polymer exhibits excellent film-forming capabilities, forming uniform, flexible coatings when applied to tablets or pellets. Its molecular weight varies by degree of substitution, typically ranging between 1,200–1,500 g/mol. Thermal stability is moderate, with decomposition occurring before melting, making it unsuitable for high-temperature processing.
Main Applications
The primary use of HPMCP is as an enteric coating for oral solid dosage forms, such as tablets and capsules. It ensures drugs bypass the stomach and release in the intestines, protecting acid-labile APIs (e.g., proton pump inhibitors) or reducing gastric side effects (e.g., NSAIDs). Beyond enteric coatings, HPMCP is employed in controlled-release formulations, where it modulates drug dissolution rates. It also serves as a binder or matrix former in multiparticulate systems. Recent research explores its potential in colon-targeted delivery and combination with other polymers for tailored release profiles.
Safety and Storage
HPMCP is generally recognized as safe (GRAS) for pharmaceutical use, with no significant toxicity reported. However, dust inhalation during handling may irritate respiratory tracts, necessitating protective equipment like masks and gloves. Storage requires a cool (below 25°C), dry environment to prevent moisture absorption, which can affect coating performance. Containers must be tightly sealed to avoid contamination. Stability studies indicate HPMCP retains its properties for at least 2–3 years under recommended conditions, though batch-specific data should be confirmed with suppliers.
B2B Procurement Guide
When sourcing HPMCP, prioritize suppliers with pharmaceutical-grade certifications (e.g., USP, EP, or JP compliance) to ensure regulatory acceptance. Request certificates of analysis (CoA) detailing substitution levels, residual solvents, and heavy metal content. For coating applications, evaluate viscosity and dissolution performance in pilot trials. Bulk pricing typically ranges from $50–$150/kg, with discounts for large orders. Consider regional suppliers to reduce logistics costs, but verify their adherence to Good Manufacturing Practices (GMP). Audit facilities if possible, focusing on quality control and batch traceability systems.
Related Manufacturers
- 主营：药用级海藻糖、药用级蜂蜜、药用级甘油、药用级羟丙甲纤维素、药用级二甲基亚砜、药用级羟苯乙酯、药用羟丙基倍他环糊精、药用二甲硅油、药用级石蜡、药用级注射蔗糖、药用级硬脂酸、聚丙烯酸钠NP700、药用卡波姆均聚物、药用糖精钠、药用三氯蔗糖、药用阿司帕坦、药用甘羟铝、药用胶囊用明胶、药用聚维酮K30
- 主营：海藻糖、柠檬酸、黄原胶、聚山梨酯、山嵛酸甘油酯、羟丙甲纤维素、羟苯甲酯钠、氯化钙、薄荷脑、泊洛沙姆、聚乙烯醇PVA、碳酸氢钠、注射蛋黄卵磷脂、注射大豆油、甘油、倍他环糊精、海藻酸钠、聚丙烯酸钠、酒石酸、丙二醇、聚乙二醇、HS15、聚氧乙烯40氢化蓖麻油
- 主营：甘氨酸、胍基乙酸、牛磺酸、沙蒿胶、黄原胶、卡拉胶、瓜尔豆胶、半胱氨酸、氨基丁酸、L-精氨酸、食品级亚硫酸氢钠、苯丙氨酸、谷氨酰胺、酪蛋白酸钠、胱氨酸、色氨酸、肌酸、富硒酵母、富铬酵母、氯化胆碱、魔芋粉、可可粉、L-抗坏血酸/vc、亮氨酸、干酪素/酪蛋白
- 主营：注射级海藻糖、三乙醇胺、甜菊糖苷、苯甲醇、二甲硅油、注射级甘露醇、牛磺酸、醋酸钠、木糖醇、黄原胶、甘露醇、大豆油、薄荷脑、注射级木糖醇、卡波姆、枸橼酸、磷酸氢二钠、磷酸氢二钾、明胶、十六醇、十八醇、聚维酮k30、注射级甘油
- 主营：海藻酸钠、乳酸链球菌素、卡拉胶、羧甲基纤维素钠、L-硒-甲基硒代半胱、温轮胶、黄原胶、苯丙氨酸、亮氨酸、苏氨酸、谷氨酸、蛋氨酸、牛磺酸、谷氨酰胺、半胱氨酸、酪蛋白酸钠、柑橘黄、聚丙烯酸钠、柠檬酸、氨基丁酸、胍基乙酸、定优胶、干酪素
- 主营：海藻酸钠、黄原胶、酪蛋白酸钠、卡拉胶、胍基乙酸、瓜尔胶/瓜尔豆胶、核苷酸、L-精氨酸、亚硫酸氢钠、苹果酸、柠檬酸、乳酸链球菌素、明胶、木糖、低聚果糖、苏氨酸、色氨酸、牛磺酸、山梨酸钾、L-半胱氨酸盐酸盐、β-胡萝卜素
- 主营：营养强化剂、抗氧化剂、增稠剂、酶制剂、酸味剂、食用色素、粉末香精、黄原胶
- 主营：营养强化剂、抗氧化剂、甜味剂、食品级增稠剂、食用色素、酶制剂、粉末香精、酸度调节剂、食品乳化剂、着色剂、抗结剂、增味剂
- 主营：卡波姆、聚维酮K30、甘油、甲基纤维素、羟苯乙酯、羟苯丙酯、丙二醇、药用蜂蜜、月桂氮卓酮、麦芽糖、三氯蔗糖、液状石蜡、固体石蜡、三乙醇胺、依地酸二钠、焦亚硫酸钠、苯扎溴铵、泊洛沙姆188/407、明胶、甜菊糖苷、注射用蔗糖
- 主营：酪蛋白酸钠、精氨酸、海藻酸钠、黄原胶、卡拉胶、维生素b、胍基乙酸、牛黄酸、双乙酸钠、大豆分离蛋白、苯丙氨酸、半胱氨酸、温轮胶、定优胶、文莱胶、明胶、木瓜蛋白酶、谷氨酰胺、甘氨酸、苏氨酸、谷氨酸、色氨酸、可可粉、抹茶粉
- 主营：丙酸钙、肉桂酸、维生素C/抗坏血酸、edta二钠、纳他霉素、抗氧剂264、抗坏血酸、双乙酸钠、聚赖氨酸、胍基乙酸、抗氧剂t501、抗氧剂1010、抗氧剂dltp、半胱氨酸盐酸盐、半胱氨酸、果胶、干酪素、苯丙氨酸、乳酸链球菌素、肉桂酸钾、色氨酸、牛磺酸、低聚木糖、酪蛋白酸钠、维生素C、vc
- 主营：架桥剂、YW100 锂萃取剂、端羧基液体丁腈橡胶、乙烯基磷酸二乙酯、溴甲酚绿、原丁酸三甲酯、10-羟基癸酸、苯乙烯磷酸、肉豆蔻酸镁、硬脂酸钴、全氟三丁胺、磷酸锰铁锂、β-磷酸三钙、十一烯酸、钨酸铝、1-乙炔基环已醇、间二异丙苯、锂硅合金、生物活性玻璃、溴代海因树脂颗粒、红铝、龙涎酮
- 主营：N-油酰基肌氨酸、环己基苯、β-溴苯乙烷、5-二甲基吡唑、乙基纤维素、菜籽油甲酯、硫酸烟酰苯胺、2-辛烯基琥珀酸酐、5二硝基水杨酸、辛酸镁、辛酸钾、有机硅季铵盐、萘钠处理液
- 主营：uv光固胶、高温胶带、机器膜胶、金属uv无影胶、夹层玻璃树脂、快速固化胶水、双马来酰亚胺、化工原料、高品质原料、树脂粉
- 主营：化工原料、诺氟羧酸、精细化工产品、氯甲基氯磺酸酯、(r)-3-氨基丁醇、兰索拉唑氯化物、氢化蓖麻油