Overview
Hyperoside Standard is a certified reference material (CRM) of the bioactive flavonoid hyperoside (quercetin-3-O-galactoside). As a naturally occurring compound found in St. John's wort (Hypericum perforatum) and other medicinal plants, it serves as a critical quality control standard in pharmaceutical and nutraceutical applications. The standard is produced under strict quality controls to ensure precise quantification in analytical methods like HPLC and LC-MS. Its use enables accurate identification and quantification of hyperoside in herbal extracts, finished products, and pharmacokinetic studies, making it indispensable for research and regulatory compliance.
Physical and Chemical Properties
Hyperoside Standard exhibits characteristic flavonoid properties, including UV absorption maxima at 257 nm and 363 nm, which are utilized in spectrophotometric assays. The compound's stability is pH-dependent, showing optimal preservation in slightly acidic to neutral conditions. Its crystalline structure and defined melting point ensure reliable performance as a reference material. The galactose moiety attached to quercetin enhances its water solubility compared to aglycone flavonoids, though organic solvents like methanol remain preferred for laboratory preparations.
Main Applications
In pharmaceutical quality control, hyperoside standard validates assay methods for St. John's wort preparations, where it serves as a marker compound. Research laboratories employ it to study the compound's antioxidant, anti-inflammatory, and neuroprotective effects. The standard is equally vital in botanical drug development, enabling standardization of herbal extracts. Regulatory agencies often require its use in stability testing and batch-to-batch consistency evaluations for herbal medicinal products containing Hypericum species.
Safety and Storage
While hyperoside itself has low acute toxicity, the standard material should be handled as a laboratory chemical with appropriate precautions. Use in fume hoods when preparing solutions, and wear protective equipment to prevent accidental exposure. Proper storage at refrigerated temperatures (2-8°C) in airtight, light-resistant containers maintains stability. Desiccants are recommended to prevent moisture absorption, which can affect weighing accuracy and compound integrity over extended periods.
B2B Procurement Guide
When sourcing hyperoside standard, prioritize suppliers that provide comprehensive documentation, including detailed certificates of analysis (CoA) with HPLC chromatograms, mass spectrometry data, and NMR verification. Batch-specific purity documentation is essential for critical applications. Consider purchasing smaller quantities initially to verify performance in your specific analytical methods. For routine use, bulk purchasing agreements with certified reference material producers can ensure consistency across longitudinal studies while potentially reducing costs by 15-30%.
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