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Hydroxythiophenol

Updated: 2026-07-22

Overview

Mercaptophenol, also known as hydroxybenzenethiol, is an aromatic compound containing both a hydroxyl (-OH) and a thiol (-SH) group. It is a versatile intermediate in organic synthesis and finds applications in various industries, including pharmaceuticals and materials science. The compound is characterized by its strong, unpleasant odor and reactivity due to the presence of the thiol group. It is commonly used as a building block for more complex molecules, leveraging its ability to participate in a variety of chemical reactions.

Physical and Chemical Properties

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Mercaptophenol is a colorless to pale yellow liquid with a density of 1.18 g/cm³. It has a boiling point of 205-207 °C and is soluble in most organic solvents, though only slightly soluble in water. The thiol group makes it highly reactive, particularly in nucleophilic substitution reactions. The compound's dual functionality (hydroxyl and thiol groups) allows it to act as a bifunctional reagent, enabling the synthesis of heterocyclic compounds and other derivatives. Its reactivity also makes it useful in metal chelation and as a corrosion inhibitor.

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Main Applications

Mercaptophenol is widely used in the pharmaceutical industry as an intermediate for the synthesis of drugs, including antibiotics and antifungal agents. Its ability to form stable complexes with metals makes it valuable in corrosion inhibition, particularly in industrial settings. In addition, it serves as a rubber additive, improving the vulcanization process. The compound is also employed in the production of agrochemicals and dyes, showcasing its versatility across multiple sectors.

Safety and Storage

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Due to its toxicity and reactivity, mercaptophenol requires careful handling. It can cause severe skin and eye irritation and is harmful if ingested or inhaled. Proper personal protective equipment (PPE), including gloves and goggles, is essential when working with this compound. Storage should be in a cool, dry, well-ventilated area, away from oxidizing agents and sources of ignition. Containers must be tightly sealed to prevent leakage and exposure to moisture, which can lead to decomposition.

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B2B Procurement Guide

When procuring mercaptophenol, it is crucial to verify the purity and quality of the product. Reputable suppliers should provide certificates of analysis (CoA) and material safety data sheets (MSDS). Bulk purchases may offer cost advantages, but ensure proper packaging to prevent spills during transport. Consider suppliers with a track record in handling hazardous chemicals and those compliant with international safety standards. Pricing can vary based on purity and order volume, so request quotes from multiple vendors to secure competitive rates.

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