Hydroxypropyl Beta-Cyclodextrin[2]
Overview
Hydroxypropyl Beta-Cyclodextrin (HP-β-CD) is a derivative of β-cyclodextrin, modified with hydroxypropyl groups to improve solubility and biocompatibility. It is widely used in pharmaceuticals, food, and cosmetics due to its ability to form inclusion complexes with hydrophobic molecules, enhancing their stability and bioavailability. HP-β-CD is preferred over native cyclodextrins for its lower toxicity and higher water solubility. Industrially, HP-β-CD is synthesized by reacting β-cyclodextrin with propylene oxide under alkaline conditions. The degree of substitution (DS) can be controlled to tailor properties for specific applications, making it versatile for drug delivery, flavor encapsulation, and more.
Physical and Chemical Properties
HP-β-CD is a white, odorless powder with a molecular weight that varies based on the degree of hydroxypropyl substitution. It exhibits high solubility in water (up to 50% w/v) and moderate solubility in organic solvents like methanol and ethanol, distinguishing it from native β-cyclodextrin, which has limited solubility. Its cavity structure allows it to encapsulate hydrophobic molecules, forming stable complexes. The compound is stable under typical storage conditions but may degrade under prolonged exposure to high temperatures or strong acids/bases. Its biodegradability and low toxicity make it environmentally friendly.
Main Applications
In pharmaceuticals, HP-β-CD is used to solubilize poorly water-soluble drugs, improving their absorption and bioavailability. It is a key excipient in oral and injectable formulations, such as the antifungal drug itraconazole. The compound also stabilizes active ingredients against oxidation or light-induced degradation. In the food industry, HP-β-CD encapsulates flavors, vitamins, and nutraceuticals, masking undesirable tastes and extending shelf life. Cosmetics leverage its solubilizing properties for fragrances and active compounds in creams and serums. Additionally, it serves as a chiral selector in analytical chemistry for separating enantiomers.
Safety and Storage
HP-β-CD is classified as generally non-toxic, with oral LD50 values exceeding 2,000 mg/kg in rodents. However, inhalation of dust or prolonged skin contact should be avoided. Use PPE (gloves, goggles) when handling large quantities. Store the powder in a tightly sealed container at room temperature (15–25°C) and low humidity. Avoid exposure to extreme pH conditions or oxidizing agents, which may degrade the compound. Shelf life typically exceeds two years when stored properly.
B2B Procurement Guide
When sourcing HP-β-CD, specify critical parameters: degree of substitution (DS, commonly 0.6–1.5), purity (>98%), and residual solvent levels. Pharmaceutical-grade material requires compliance with USP/EP/JP standards and additional documentation like Certificates of Analysis (CoA). Bulk purchases (100+ kg) often reduce costs by 10–30%. Reputable suppliers include Ashland, Roquette, and CycloLab. Lead times vary; ensure compatibility with production schedules. For R&D, smaller quantities (1–10 kg) are available from Sigma-Aldrich or TCI Chemicals.
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