Overview
Hydroxyproline is a non-essential amino acid derived from proline, primarily found in collagen and connective tissues. It is crucial for maintaining the structural integrity of collagen, the most abundant protein in mammals. Unlike other amino acids, hydroxyproline is not directly incorporated into proteins during translation but is formed by post-translational modification of proline residues in collagen. This amino acid is widely studied in biomedical research for its role in tissue repair, wound healing, and bone formation. It is also used in pharmaceuticals and nutritional supplements to support joint health and skin elasticity. Hydroxyproline is available in various grades, with research-grade purity (≥98%) being the most common for laboratory use.
Physical and Chemical Properties
Hydroxyproline appears as a white crystalline powder with a molecular weight of 131.13 g/mol. It has a density of 1.38 g/cm³ and decomposes at 274-276°C. The compound is soluble in water and slightly soluble in ethanol, making it suitable for aqueous solutions in laboratory settings. Its chiral nature means it exists in two enantiomers: L-hydroxyproline, which is biologically active, and D-hydroxyproline, which is rare in nature. The L-form is the most commonly used in research and industrial applications. Hydroxyproline's unique structure, featuring a hydroxyl group on the pyrrolidine ring, contributes to its role in stabilizing collagen triple helices.
Main Applications
Hydroxyproline is extensively used in biomedical research to study collagen metabolism, fibrosis, and connective tissue disorders. It serves as a biomarker for collagen turnover in diseases like osteoporosis and arthritis. In pharmaceuticals, it is incorporated into formulations aimed at promoting wound healing and tissue regeneration. Nutritional supplements often include hydroxyproline to support joint health, skin elasticity, and connective tissue repair. It is also used in cosmetic products for its anti-aging properties. Additionally, hydroxyproline is employed in the food industry as a flavor enhancer and in agricultural research to improve crop resilience.
Safety and Storage
Hydroxyproline is generally non-toxic but should be handled with care to avoid inhalation or contact with eyes and skin. Proper personal protective equipment (PPE), such as gloves and safety goggles, is recommended when working with the compound. Storage conditions are critical to maintaining its stability. Hydroxyproline should be kept in a cool, dry place away from direct light and moisture. Sealed containers are preferable to prevent degradation. Long-term storage at temperatures below 25°C is ideal to preserve its chemical integrity.
B2B Procurement Guide
When procuring hydroxyproline for B2B purposes, verify the purity level (≥98% for research-grade applications) and confirm the CAS number (51-35-4) to ensure product authenticity. Reputable suppliers should provide certificates of analysis (CoA) detailing purity, moisture content, and other relevant parameters. Bulk purchases may offer cost advantages, but consider storage capabilities to avoid degradation. For specialized applications, such as pharmaceuticals or cosmetics, opt for pharmaceutical-grade hydroxyproline, which undergoes stricter quality controls. Lead times and supplier reliability are also key factors to consider, especially for time-sensitive projects.
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