Overview
α-Hydroxyhippuric acid (α-HHA) is an organic compound derived from glycine and benzoic acid. It is a metabolite of certain biochemical pathways and is often used in research to study metabolic processes. The compound is known for its stability and solubility in both aqueous and organic solvents, making it versatile for laboratory and industrial applications. α-HHA is synthesized through the conjugation of glycine and benzoic acid, followed by hydroxylation at the α-position. This process yields a compound with distinct chemical properties, useful in various biochemical assays and synthetic chemistry applications.
Physical and Chemical Properties
α-Hydroxyhippuric acid appears as a white to off-white crystalline powder with a molecular weight of 195.17 g/mol. It has a melting point of approximately 140-145°C and is soluble in water and common organic solvents such as ethanol and methanol. The compound is stable under normal storage conditions but may degrade when exposed to extreme temperatures or prolonged sunlight. Key chemical properties include its biodegradability and reactivity under specific conditions. These characteristics make it suitable for use in biochemical research, where precise control over reaction conditions is essential. The compound's solubility profile also allows for easy integration into aqueous and organic systems.
Main Applications
α-Hydroxyhippuric acid is primarily used in biochemical and medical research as a metabolite in studies involving glycine and benzoic acid pathways. It serves as a reference standard in analytical chemistry and is employed in the synthesis of more complex organic compounds. In industrial settings, α-HHA is utilized in the production of specialty chemicals and pharmaceuticals. Its role as an intermediate in synthetic chemistry makes it valuable for developing new compounds with specific functional properties. Researchers also explore its potential in environmental science, particularly in biodegradation studies.
Safety and Storage
When handling α-hydroxyhippuric acid, it is essential to follow standard laboratory safety protocols. The compound should be stored in a cool, dry place, away from direct sunlight and moisture. Proper labeling and secure containers are recommended to prevent accidental exposure. Personal protective equipment (PPE), including gloves and safety goggles, should be worn to minimize contact with skin and eyes. In case of inhalation or ingestion, seek medical attention immediately. The compound is not known to be highly toxic, but precautionary measures are advised to ensure safe handling and storage.
B2B Procurement Guide
For B2B buyers, sourcing high-quality α-hydroxyhippuric acid involves verifying supplier credentials and product specifications. Key factors to consider include purity levels, packaging options, and batch consistency. Reputable suppliers often provide certificates of analysis (CoA) to confirm the compound's quality. Prices vary depending on purity and quantity, with research-grade α-HHA typically ranging from $50 to $200 per gram. Bulk purchases may offer cost savings, but buyers should ensure that storage conditions are maintained during transit. Procurement professionals should also evaluate lead times and supplier reliability to meet project timelines.
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