Overview
Hydroxyethyl-β-Cyclodextrin (HE-β-CD) is a derivative of β-cyclodextrin, modified by hydroxyethyl groups to enhance its solubility and inclusion capacity. It is widely used in industries requiring solubilization of hydrophobic compounds, such as pharmaceuticals and cosmetics. HE-β-CD is preferred for its low toxicity and biocompatibility, making it suitable for oral and topical applications. The compound’s cyclic oligosaccharide structure forms a hydrophobic cavity that can encapsulate guest molecules, improving their stability and bioavailability. This property is leveraged in drug formulations to increase the solubility of poorly water-soluble active pharmaceutical ingredients (APIs).
Physical and Chemical Properties
HE-β-CD appears as a white to off-white powder with high water solubility, a critical feature for its role as a solubilizing agent. Unlike native β-cyclodextrin, hydroxyethyl substitution reduces its crystallinity and improves its amorphous nature, further enhancing solubility. Its molecular weight varies depending on the degree of substitution (DS), typically ranging from 1,300 to 1,500 g/mol. The compound is stable under normal storage conditions but may decompose at high temperatures. It is non-hygroscopic and compatible with a wide range of pH levels, making it versatile for formulation use.
Main Applications
In the pharmaceutical industry, HE-β-CD is used to enhance the solubility and stability of drugs, particularly in injectable and oral formulations. It is also employed in cosmetic products to stabilize fragrances and active ingredients. In the food sector, it acts as a carrier for flavors and vitamins. Research applications include its use as a chiral selector in chromatography and a tool for studying protein-ligand interactions. Its ability to form inclusion complexes with hydrophobic molecules makes it valuable in nanotechnology and drug delivery systems.
Safety and Storage
HE-β-CD is classified as non-toxic and is generally recognized as safe (GRAS) for oral consumption. However, prolonged exposure to the powder form should be avoided to prevent respiratory irritation. Proper handling includes using personal protective equipment (PPE) such as gloves and masks. Storage recommendations include keeping the product in a cool, dry place, away from direct sunlight and moisture. The compound is stable under ambient conditions but should be protected from extreme temperatures to prevent degradation.
B2B Procurement Guide
When procuring HE-β-CD, buyers should prioritize suppliers who provide detailed certificates of analysis (COA) and material safety data sheets (MSDS). Key specifications to verify include the degree of substitution (DS), purity (typically >98%), and residual solvent levels. Bulk buyers should negotiate prices based on volume, as costs can vary significantly. It is advisable to request samples for quality testing before large-scale purchases. Leading manufacturers are located in China, Europe, and the U.S., with pricing influenced by regional supply chains.
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