Overview
Hydroxyacetophenone, also known as 4-hydroxyacetophenone, is an organic compound belonging to the class of aromatic ketones. It is characterized by a hydroxyl group attached to the benzene ring, making it a versatile intermediate in chemical synthesis. This compound is widely used in the pharmaceutical industry for the production of drugs and active pharmaceutical ingredients (APIs). Its role as a fragrance ingredient is also notable, contributing to the formulation of perfumes and flavoring agents.
Physical and Chemical Properties
Hydroxyacetophenone appears as a white to off-white crystalline powder with a melting point of 109-112 °C and a boiling point of 296 °C. It has a density of 1.109 g/cm³ and is soluble in organic solvents like ethanol and ether, as well as hot water. The presence of both a hydroxyl group and a ketone functional group in its structure allows for various chemical reactions, including oxidation and condensation. These properties make it a valuable building block in organic synthesis and industrial applications.
Main Applications
In the pharmaceutical sector, hydroxyacetophenone serves as a key intermediate for synthesizing analgesics, anti-inflammatory drugs, and other therapeutic compounds. Its UV-absorbing properties are utilized in sunscreens and coatings. The fragrance industry employs hydroxyacetophenone in the production of perfumes and essential oils due to its pleasant aromatic characteristics. Additionally, it is used in the synthesis of fine chemicals and agrochemicals, highlighting its broad utility in chemical manufacturing.
Safety and Storage
Hydroxyacetophenone should be handled with care, as it may cause skin and eye irritation. Proper personal protective equipment (PPE), including gloves and safety goggles, is recommended during handling. Storage conditions are critical to maintaining the compound's stability. It should be kept in a cool, dry, and well-ventilated area, away from direct sunlight and moisture. Proper labeling and segregation from incompatible substances are also essential to prevent accidents.
B2B Procurement Guide
When procuring hydroxyacetophenone, buyers should prioritize suppliers who provide detailed specifications, including CAS number (99-93-4) and purity levels (typically 98% or higher). Bulk purchases often qualify for discounts, so inquire about volume pricing. Lead times can vary depending on supplier inventory and production schedules. It's advisable to establish long-term relationships with reputable manufacturers to ensure consistent quality and reliable supply chains. Certificates of analysis (CoA) and material safety data sheets (MSDS) should always be requested.
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