Overview
Hydroxy-terminated polylactic acid (PLA-OH) is a functionalized variant of polylactic acid, a biopolymer derived from renewable resources like corn starch or sugarcane. The hydroxyl end groups enhance its reactivity, making it suitable for further chemical modifications such as copolymerization or cross-linking. As a biodegradable and biocompatible material, PLA-OH aligns with global sustainability initiatives. Its production involves ring-opening polymerization of lactide monomers, with controlled termination to preserve hydroxyl functionality. The material is classified as Generally Recognized As Safe (GRAS) by regulatory bodies for specific applications.
Physical and Chemical Properties
PLA-OH exhibits typical thermoplastic behavior with a glass transition temperature (Tg) around 55-60°C and melting points between 150-160°C for semi-crystalline grades. The hydroxyl functionality (typically 0.5-2.0 meq/g) allows covalent bonding with isocyanates, anhydrides, or other reactive compounds. Its mechanical properties depend on molecular weight and crystallinity, with tensile strength ranging from 30-60 MPa. Unlike standard PLA, the hydroxyl-terminated version shows improved compatibility with polar substrates due to terminal group interactions. Thermal degradation begins at ~200°C, releasing lactide monomers.
Main Applications
In the medical field, PLA-OH serves as a base material for resorbable surgical sutures, orthopedic fixation devices, and tissue engineering scaffolds due to its controlled degradation profile (6 months to 2 years in vivo). The reactive end groups enable covalent drug attachment in sustained-release formulations. The packaging industry utilizes PLA-OH for compostable films and containers, often blended with other biopolymers to improve flexibility. In textiles, it's processed into biodegradable fibers for disposable hygiene products. Emerging applications include 3D printing resins and adhesive formulations where eco-friendly properties are prioritized.
Safety and Storage
PLA-OH presents minimal toxicity risks but requires standard polymer handling precautions. Dust generation during processing may cause mechanical irritation to respiratory systems—use local exhaust ventilation and PPE like N95 masks. The material is not classified as hazardous under GHS standards. Storage recommendations include double-layer moisture-proof packaging with desiccants to prevent hydrolysis. Bulk quantities should be palletized in climate-controlled warehouses (<30°C, <60% RH). Shelf life typically exceeds 24 months when properly stored, though viscosity may gradually increase due to slow post-polymerization.
B2B Procurement Guide
Industrial buyers should specify these critical parameters: molecular weight (Mn 10,000-100,000 g/mol), hydroxyl value (0.8-1.8 meq/g preferred for most applications), residual lactide content (<1% for medical grades), and optical purity (D-isomer <5% for crystalline grades). Request certificates of analysis for each batch, including GPC data for molecular weight distribution. For medical applications, ensure suppliers provide ISO 13485 certification and biocompatibility test reports (ISO 10993 series). Consider FOB terms from manufacturers in China or EU to balance cost and quality, with MOQs commonly 500kg-1 ton for standard grades.
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