Overview
Hydroxamic acids are a class of organic compounds characterized by the functional group -CONHOH. They are derivatives of carboxylic acids where the hydroxylamine group replaces the hydroxyl group. These compounds exhibit unique chemical properties due to their ability to form stable complexes with metal ions. The hydroxamic acid structure allows for both oxygen and nitrogen coordination to metals, making them particularly effective as chelating agents.
Physical and Chemical Properties
Hydroxamic acids typically appear as colorless to pale yellow solids or liquids, depending on their molecular weight and substituents. They are generally soluble in water and polar organic solvents due to their polar nature. The most distinctive chemical property of hydroxamic acids is their strong chelating ability, particularly for transition metals like iron, copper, and zinc. This property stems from their bidentate ligand capability, where both the oxygen and nitrogen atoms can coordinate to metal centers. Hydroxamic acids are weak acids with pKa values typically ranging from 8 to 10. They are thermally unstable and may decompose when heated, especially at temperatures above 150°C.
Main Applications
In industrial settings, hydroxamic acids are primarily used as metal extractants in hydrometallurgical processes, particularly for uranium and rare earth elements. Their strong chelating properties make them effective in separating metals from ores. The pharmaceutical industry utilizes hydroxamic acids as enzyme inhibitors, particularly for metalloenzymes. Several hydroxamic acid derivatives are used in medications, including histone deacetylase inhibitors for cancer treatment. Other applications include use as corrosion inhibitors, analytical reagents for metal detection, and in polymer stabilization. Some derivatives serve as intermediates in organic synthesis.
Safety and Storage
Hydroxamic acids require careful handling due to their potential health effects. Many derivatives can cause skin and eye irritation, and some may be harmful if ingested or inhaled. Proper storage involves keeping containers tightly sealed in a cool, dry place away from oxidizing agents. Some derivatives may require refrigeration to prevent decomposition. For laboratory use, hydroxamic acids should be handled in a fume hood with appropriate personal protective equipment. Special attention should be paid to the thermal instability of these compounds. They should not be exposed to high temperatures or strong acids, which may cause decomposition.
B2B Procurement Guide
When procuring hydroxamic acids commercially, it's essential to specify the exact derivative required, as properties and applications vary significantly with different R groups in the RCONHOH structure. Key considerations include purity requirements (typically 95-99% for industrial applications), packaging specifications (often 25kg drums for bulk quantities), and certification of analysis. Price varies significantly based on purity and specific derivative, with research-grade materials commanding higher prices than industrial-grade products. Lead times can vary from 2-8 weeks depending on the derivative and quantity required. It's advisable to request small samples for testing before placing large orders.
Related Manufacturers
- 主营：渗透剂、催干剂、洗涤剂、防润滑油、棕榈油酸、工业润滑剂、矿石浮选剂、金属切削液、石油磺酸钠、石油磺酸钡、表面活性剂、润滑防锈剂、工业级妥尔油、单油酸酯聚氧乙、环氧树脂固化剂
- 主营：辛基羟肟酸、精细化工品、润滑油、有机中间体
- 主营：全氟三丁胺、全氟三乙胺、全氟三丙胺、羟基磷灰石、甲乙基、乙氧基、全氟聚醚、全氟萘烷、全氟己酮、生物活性玻璃、布洛芬、溴壬烷、磷酸铵、褪黑素、嘧啶钠、莪术油、显色剂、叔丁醇、茜素红、异戊醇、脯氨酸、茚三酮、氯唑沙
- 主营：二甲基亚砜、乙二醇、丙二醇、DMAC
- 主营：辛基羟肟酸、高铁酸钾
- 主营：花生酸、碳酸钠、单氟磷酸钠、丁基羟基茴香醚、鱼大豆酵母原料
- 主营：辛酰氧肟酸、全氟三丁胺、木质素、吉氏色素
- 主营：优氯净、甘氨酸、切削液、烷基羟肟酸钠捕收剂、水杨酸、硫酸锰、平平加、滑石粉、牛磺酸、白僵菌、磷酸铁、铵明矾、蛋白胨、碳酸镁、磷酸铝、戊二醛、纤维素、硫化钠、硫化钡、黄蜂蜡、硫化钙、氯化锌、氯化锰、氧化锑、氧化锆、氧化锌
- 主营：白炭黑、白僵菌、eva乳液、烷基羟肟酸市场价格、棕榈蜡、pvc发泡剂、聚碳酸酯、聚乙烯蜡、苯甲酸铵、t-31固化剂
- 主营：元明粉、丙酸钙、玻璃粉、烷基羟肟酸选矿药剂、冰醋酸、液压油、浮选油、草酸铵、生石灰、硅酸钠、单宁酸、胶泥粉、降阻剂、冰晶石、二萘酚、促进剂、熟石灰、三甘醇、大豆蜡、泡花碱、铵明矾、石英砂、丙二醇、edta四钠、edta二钠、维生素b1
- 主营：氯化锌、玻璃粉、冰醋酸、烷基羟肟酸现货、茶皂素、甘氨酸、渗透剂、棕榈酸、氯化钾、靛蓝粉、磷酸钙、eva乳液、氟化钾、堵漏王、早强剂、三甘醇、亚油酸、木质素、氟化钠、铵明矾、pvc树脂、富马酸、白糊精、壳聚糖、苯丙乳液、三乙二醇
- 主营：优氯净、甘氨酸、磷酸硼、烷基羟肟酸选矿药剂、水杨酸、硫酸锰、苯甲醇、平平加、正辛烷、一乙胺、磷酸氢、白僵菌、蛋白胨、碳酸镁、磷酸铝、异丁酸、叔丁醇、硫化钡、木质素、醋酸钡、硫化钙、氯化锌、黄原胶、磺酸钙、氟化镁、异丙醇
- 主营：硫酸钡、碳酸钙、硅溶胶、苄基胂酸、甲基磺酸、氨基磺酸、正硅酸乙酯、多聚甲醛
- 主营：优氯净、二萘酚、硫酸锌、烷基羟肟酸选矿药剂、封口蜡、甘露醇、水杨酸、硫酸锰、防染盐、正辛烷、牛磺酸、白僵菌、冰醋酸、铵明矾、肉桂醇、碳酸镁、肉桂醛、磷酸铝、戊二醛、沸石粉、硫化钠、硫化钡、硫化钙、氯化锌、黄原胶、磺酸钙
- 主营：封口蜡、水杨酸、正辛烷、烷基羟肟酸选矿药剂、肉桂醇、珠光片、碳酸镁、肉桂醛、建筑料、磷酸铝、肉桂酸、戊二醛、切削液、叔丁醇、清洗剂、硫化钠、硫化钡、升硫醚、硫化钙、杀菌液、氯化锌、黄原胶、助染剂、椰子油、氯化锰、氧化锑