Overview
Human Thioredoxin (Trx) is a small, ubiquitous protein that plays a pivotal role in maintaining cellular redox balance. It is involved in numerous biological processes, including DNA synthesis, antioxidant defense, and regulation of transcription factors. Trx is characterized by its active site sequence Cys-Gly-Pro-Cys, which enables it to reduce disulfide bonds in target proteins. Trx is widely studied for its therapeutic potential in diseases such as cancer, neurodegenerative disorders, and inflammatory conditions. Its ability to modulate oxidative stress makes it a valuable tool in both research and clinical applications. The protein is typically produced via recombinant DNA technology, ensuring high purity and consistency for laboratory and industrial use.
Physical and Chemical Properties
Human Thioredoxin is a small protein with a molecular weight of approximately 12 kDa. It is highly soluble in aqueous solutions and exhibits stability across a range of pH levels. The protein's redox activity is attributed to its active site, which undergoes reversible oxidation and reduction. Trx is heat-stable and retains its activity under moderate temperature conditions. Its structure includes a central beta-sheet flanked by alpha-helices, a common motif in redox-active proteins. The protein's stability and solubility make it suitable for various experimental and industrial applications.
Main Applications
Human Thioredoxin is extensively used in biochemical and biomedical research. It serves as a model protein for studying redox regulation and oxidative stress. In drug development, Trx is investigated for its potential to mitigate oxidative damage in diseases like cancer and Alzheimer's. Additionally, Trx is employed in biotechnology for protein refolding and as a fusion tag to enhance the solubility of recombinant proteins. Its therapeutic applications include the development of antioxidant therapies and anti-inflammatory drugs. The protein's versatility makes it a staple in both academic and industrial settings.
Safety and Storage
Human Thioredoxin should be handled with caution to avoid exposure. Use gloves, lab coats, and eye protection when working with the protein. In case of contact, rinse thoroughly with water and seek medical advice if irritation persists. For long-term storage, Trx should be kept at -20°C in a tightly sealed container. Avoid repeated freeze-thaw cycles to maintain stability. Lyophilized powder is stable for extended periods when stored under recommended conditions. Always check the manufacturer's guidelines for specific storage requirements.
B2B Procurement Guide
When procuring Human Thioredoxin for B2B purposes, prioritize suppliers with a proven track record in protein production. Verify the product's purity (typically >95%) and endotoxin levels, as these factors can impact experimental outcomes. Bulk purchases may offer cost advantages, so negotiate with suppliers for volume discounts. Ensure the protein is shipped with adequate cold chain logistics to preserve its integrity. Request certificates of analysis and stability data to confirm product quality before finalizing orders.
Related Manufacturers
- 主营：ELISA试剂盒、PCR试剂盒、科研试剂
- 主营：igg抗体、试剂盒、粗纤维、糖蛋白、脂蛋白、人瘦素、人蛋白、人胆酸、猪睾酮、烯二酮、nad激酶、测试盒、牛瘦素、牛胆酸、原果胶、磷酸酶、犬肾素、含水量、甜菜碱、igm抗体、dna抗体、磷脂酶、大鼠超、犬叶酸、样受体
- 主营：检测方、钠尿肽、试剂盒、结合蛋白、微球蛋白、抗胰蛋白酶、蛋白磷酸酶、核心域蛋白1、激活蛋白激酶、大鼠klotho蛋白、同源物、ep300检测、大鼠c-肽(、淋巴瘤因子、死亡激动剂、大鼠e选择素、大鼠janus激酶、大鼠ⅱ型胶原、大鼠ⅳ型胶原、细胞激活因子、大鼠ⅲ型胶原、大鼠nadh脱氢酶1、大鼠ⅵ型胶原α1、elisa 检测试剂盒
- 主营：血浆淀粉样蛋白P、ELISA试剂盒、抗体
- 主营：科研试剂盒、酶免试剂盒、elisa试剂盒、人硫氧还蛋白还原酶1、细胞、生物试剂、进口ELISA试剂盒、PCR试剂盒、生化测试盒
- 主营：酶cγ链、α2巨球、素d合成、纤连蛋白、抗组蛋白、蛋白样环、敏感蛋白、蛋白重链、乳球蛋白、蛋白激酶、钙调蛋白、肌醇抗体、牛骨钙素、金属肽酶、钩端螺旋、高血糖素、小鼠α1抗、ELISA试剂盒、pcr检测试剂、生化检测试剂
- 主营：硫氧还蛋白、elisa试剂盒
- 主营：Elisa试剂盒、检测试剂盒、鼠elisa试剂盒、人elisa试剂盒、PCR检测试剂盒、生物试剂盒
- 主营：人检测试剂盒、检测试剂盒
- 主营：试剂盒、微生物细胞色素、细胞、人类风湿因子、ELISA检测试剂盒、原代培养细胞、类风湿检测试剂、酶联免疫试剂盒、微生物检测试剂、抗体检测试剂盒、炎症因子试剂盒、血清检测试剂盒、肿瘤标志物试剂、真菌检测试剂盒、生化分析试剂盒、HEC-1-A 细胞、细胞株、肺癌体外细胞模型、乳腺肿瘤细胞株、小鼠结肠癌细胞、多发性骨髓瘤细胞、肠道癌细胞系、髓母细胞瘤冻存株、乳腺肿瘤细胞、结肠癌细胞系
- 主营：蛋白试剂盒、Elisa试剂盒、生化试剂盒、细胞试剂盒
- 主营：试剂盒、ELISA试剂盒、PCR试剂盒、科研细胞系
- 主营：ELISA检测试剂盒
- 主营：ELISA试剂盒、生化检测试剂盒、PCR试剂盒、大鼠ELISA试剂盒、小鼠ELISA试剂盒、兔ELISA试剂盒、鸡ELISA试剂盒
- 主营：试剂盒