Overview
Human lactoferrin (hLF) is a bioactive glycoprotein belonging to the transferrin family, predominantly found in human colostrum and milk. It exhibits iron-binding capabilities and broad-spectrum antimicrobial activity against bacteria, viruses, and fungi. Structurally, it consists of a single polypeptide chain with two iron-binding lobes, enabling its multifunctional roles in immunity and nutrition. As a natural component of innate immunity, lactoferrin is increasingly utilized in nutraceuticals and therapeutic formulations. Its recombinant versions are produced via microbial or mammalian expression systems to meet industrial demand, ensuring scalability and consistency for B2B applications.
Physical and Chemical Properties
Lactoferrin is a globular protein with a molecular weight of approximately 80 kDa, often appearing as a hygroscopic powder. Its iron-saturated form (holo-lactoferrin) is pinkish due to iron coordination, while the iron-free form (apo-lactoferrin) is colorless. The protein is stable under acidic conditions (pH 2.5–6) but denatures at temperatures above 60°C, losing its functional properties. Solubility is optimal in neutral to slightly acidic aqueous solutions. Its isoelectric point (pI) ranges between 8.0 and 8.5, influencing purification methods such as ion-exchange chromatography. Analytical techniques like SDS-PAGE and HPLC are used to assess purity, which is critical for pharmaceutical-grade applications.
Main Applications
In infant nutrition, lactoferrin replicates the immune benefits of breast milk, reducing infections and supporting gut health. It is added to premium infant formulas and pediatric supplements. Pharmaceutical applications include wound healing creams, oral care products (for its anti-caries effects), and even anticancer therapies due to its apoptosis-inducing properties. The nutraceutical industry incorporates lactoferrin into immune-boosting supplements, sports nutrition products, and functional foods. Its iron-binding capacity also makes it a natural preservative in food packaging, inhibiting microbial growth. Research continues to explore its potential in treating inflammatory diseases and viral infections.
Safety and Storage
Lactoferrin is non-toxic and well-tolerated, with GRAS status in many countries. Rare allergic reactions may occur in individuals sensitive to dairy proteins. Proper storage at 2-8°C in moisture-proof containers is essential to prevent degradation. Lyophilized forms offer longer shelf life (up to 2 years) compared to liquid formulations. Handling should adhere to GMP standards to avoid contamination. Suppliers must provide certificates of analysis (CoA) detailing endotoxin levels, microbial counts, and heavy metal content to ensure compliance with regulatory standards like USP or EP.
B2B Procurement Guide
Buyers should prioritize suppliers with ISO 13485 or FSSC 22000 certifications for quality assurance. Key specifications include purity (≥90% for most applications), iron saturation level (adjustable per use case), and endotoxin limits (<10 EU/mg for injectables). Bulk pricing tiers apply for orders exceeding 10 kg, with discounts for long-term contracts. Consider recombinant variants (e.g., from yeast) for cost efficiency, though natural-sourced lactoferrin may be preferred for certain markets. Audit supply chains for ethical sourcing, especially for human-derived products. Sample testing for bioactivity (e.g., bacteriostatic assays) is recommended before large-scale procurement.
Related Manufacturers
- 主营：人乳铁传递蛋白、ELISA试剂盒、PCR试剂盒、科研试剂
- 主营：乳铁传递蛋白、试剂盒、ELISA试剂盒、ELISA检测试剂盒
- 主营：试剂盒、磷酸酶、dna抗体、蛋白酶、人果糖、人组织、人tgf-β、联蛋白、体蛋白、人抗网、人gtp酶、磷脂酶、氧化酶、抑制剂、抗dna酶、cplcelisa、双链dna、氧脂素、头包类、阻滞剂、头包啦、检测卡、q热抗体、胶原c内、4脱氢酶
- 主营：人多巴胺elisa试剂盒、ELISA试剂盒、抗体
- 主营：ELISA试剂盒、PCR试剂盒、生化试剂盒、人乳铁传递蛋白、科研试剂
- 主营：检测方、钠尿肽、试剂盒、结合蛋白、微球蛋白、抗胰蛋白酶、蛋白磷酸酶、核心域蛋白1、激活蛋白激酶、大鼠klotho蛋白、同源物、ep300检测、大鼠c-肽(、淋巴瘤因子、死亡激动剂、大鼠e选择素、大鼠janus激酶、大鼠ⅱ型胶原、大鼠ⅳ型胶原、细胞激活因子、大鼠ⅲ型胶原、大鼠nadh脱氢酶1、大鼠ⅵ型胶原α1、elisa 检测试剂盒
- 主营：Elisa试剂盒、检测试剂盒、鼠elisa试剂盒、人elisa试剂盒、PCR检测试剂盒、生物试剂盒
- 主营：人乳铁传递蛋白、检测试剂盒
- 主营：Ig人乳铁传递蛋白、ELISA试剂盒、PCR试剂盒、科研试剂
- 主营：人乳铁传递蛋白、试剂盒
- 主营：试剂盒、ELISA试剂盒、PCR试剂盒、科研细胞系
- 主营：乳铁传递蛋白、elisa试剂盒、试剂盒、抗体
- 主营：人乳铁传递蛋白、ELISA检测试剂盒
- 主营：ELISA、分光光度法、微量法、人试剂盒、人ELISA试剂盒、ELISA试剂盒、大鼠试剂盒、小鼠试剂盒、植物试剂盒、酶联免疫法、MEGAZYME、大鼠ELISA试剂盒、小鼠ELISA试剂盒、植物ELISA 试剂盒、白介素试剂盒、细胞因子试剂盒、激素试剂盒、科研试剂盒、化学试剂、检测试剂盒、土壤试剂盒、土壤酶活性检测
- 主营：ELISA试剂盒、高灵敏度试剂盒、试剂盒厂家、人ELISA试剂盒、特种蛋白检测ELISA试剂盒、小鼠ELISA试剂盒、大鼠ELISA试剂盒、仓鼠ELISA试剂盒、豚鼠ELISA试剂盒、鸡ELISA试剂盒、鸭ELISA试剂盒、牛ELISA试剂盒、羊ELISA试剂盒、马ELISA试剂盒、猴ELISA试剂盒、猪ELISA试剂盒、犬ELISA试剂盒、兔ELISA试剂盒、鱼ELISA试剂盒、植物ELISA试剂盒、土壤ELISA试剂盒、定性ELISA试剂盒、肿瘤标志物检测ELISA试剂盒、传染病检测ELISA试剂盒