Overview
Human Kallikrein, also known as Kallikrein-1, is a serine protease enzyme that is widely studied for its role in physiological processes such as blood pressure regulation and inflammation. It is primarily produced in the kidneys, pancreas, and salivary glands. The enzyme cleaves kininogen to release kinins, which are potent vasodilators. In medical research, Human Kallikrein is used to study its involvement in diseases like hypertension and cancer. Its ability to modulate inflammatory responses makes it a target for therapeutic development. The enzyme is also utilized in diagnostic assays to measure its activity in biological samples.
Physical and Chemical Properties
Human Kallikrein is a glycoprotein with a molecular weight ranging between 25-30 kDa. It appears as a white to off-white powder and is soluble in water and saline solutions. The enzyme exhibits optimal activity at a neutral pH and is sensitive to extreme temperatures and pH levels. As a serine protease, Human Kallikrein requires specific cofactors for its activity. It is stabilized by calcium ions and inhibited by serine protease inhibitors like aprotinin. The enzyme's stability under various storage conditions is critical for its application in research and diagnostics.
Main Applications
Human Kallikrein is extensively used in medical research to investigate its role in cardiovascular diseases, inflammation, and cancer. Its ability to generate kinins makes it valuable for studying vasodilation and blood pressure regulation. In the pharmaceutical industry, Human Kallikrein is explored as a potential therapeutic target for conditions like hypertension and inflammatory disorders. Diagnostic laboratories use it to develop assays for measuring kallikrein activity in patient samples, aiding in disease diagnosis and monitoring.
Safety and Storage
Human Kallikrein should be handled with care to avoid inhalation or skin contact, as it may cause irritation. Always use personal protective equipment, including gloves and lab coats, when working with the enzyme. For long-term storage, keep Human Kallikrein at -20°C in a dry environment to maintain its stability. Avoid repeated freeze-thaw cycles, as they can degrade the enzyme's activity. Proper labeling and secure storage are essential to prevent contamination and ensure safety.
B2B Procurement Guide
When procuring Human Kallikrein for B2B purposes, prioritize suppliers who provide certificates of analysis (CoA) detailing purity (≥90%) and enzymatic activity. GMP-certified suppliers are preferred for consistent quality. Consider the enzyme's intended use—whether for research, diagnostics, or therapeutic development—as this will dictate the required purity and activity levels. Bulk purchases may offer cost savings, but ensure proper storage facilities are available to maintain product integrity.
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