Overview
Human fibrinogen is a glycoprotein synthesized in the liver and crucial for blood coagulation. As the precursor to fibrin, it polymerizes during clotting to form a mesh that stabilizes platelet plugs. In medical settings, purified fibrinogen is used to manage bleeding disorders and as a biomaterial in surgeries. Pharmaceutical-grade fibrinogen is derived from human plasma and undergoes rigorous pathogen reduction. Its therapeutic applications are expanding, particularly in trauma care and regenerative medicine, where it serves as a scaffold for tissue repair.
Physical and Chemical Properties
Fibrinogen is a large (340 kDa) hexameric protein composed of two sets of three polypeptide chains (α, β, γ). It remains stable as a lyophilized powder but degrades rapidly in solution if not refrigerated. The protein’s isoelectric point is ~5.5, and it exhibits UV absorbance at 280 nm due to tyrosine and tryptophan residues. Under physiological conditions, thrombin cleaves fibrinogen to release fibrinopeptides, triggering spontaneous polymerization. This reaction is calcium-dependent and forms insoluble fibrin clots. The protein’s solubility decreases at temperatures above 37°C, a property exploited in heat-precipitation purification methods.
Main Applications
In clinical practice, fibrinogen concentrates treat congenital fibrinogen deficiencies (e.g., afibrinogenemia) and acquired hypofibrinogenemia from trauma or liver disease. It’s also a key component of fibrin sealants, which control bleeding in surgeries like cardiovascular or orthopedic procedures. Beyond hemostasis, fibrinogen is used in 3D bioprinting and tissue engineering due to its biocompatibility and ability to support cell adhesion. Research explores its role in drug delivery systems, where fibrin matrices slowly release growth factors or antibiotics.
Safety and Storage
As a plasma-derived product, fibrinogen carries risks of pathogen transmission unless treated with solvent/detergent or nanofiltration. Storage requires strict temperature control: lyophilized vials last 2–3 years at 2–8°C, while reconstituted solutions must be used within 4 hours to prevent bacterial growth. Thrombotic events are a rare but serious adverse effect, particularly in patients with cardiovascular risks. Contraindications include allergies to bovine proteins (present in some stabilizers) and disseminated intravascular coagulation (DIC). Always monitor plasma fibrinogen levels during therapy.
B2B Procurement Guide
When sourcing fibrinogen, prioritize suppliers compliant with Good Manufacturing Practice (GMP) and holding certifications like EMA or FDA approval. Key specifications include functional activity (≥80% clottable protein), purity (≥95% by SDS-PAGE), and endotoxin levels (<5 IU/mg). Bulk buyers should request batch-specific CoA (Certificate of Analysis) and viral safety documentation. For research-grade fibrinogen, consider recombinant alternatives to avoid human-derived material. Lead times vary; pharmaceutical-grade orders may require 8–12 weeks due to stringent testing.
Related Manufacturers
- 主营：大鼠白介素、小鼠脂联素、表皮生长因子、重组蛋白、ELISA试剂盒、细胞因子
- 主营：ELISA试剂盒、高灵敏度试剂盒、试剂盒厂家、人ELISA试剂盒、特种蛋白检测ELISA试剂盒、小鼠ELISA试剂盒、大鼠ELISA试剂盒、仓鼠ELISA试剂盒、豚鼠ELISA试剂盒、鸡ELISA试剂盒、鸭ELISA试剂盒、牛ELISA试剂盒、羊ELISA试剂盒、马ELISA试剂盒、猴ELISA试剂盒、猪ELISA试剂盒、犬ELISA试剂盒、兔ELISA试剂盒、鱼ELISA试剂盒、植物ELISA试剂盒、土壤ELISA试剂盒、定性ELISA试剂盒、肿瘤标志物检测ELISA试剂盒、传染病检测ELISA试剂盒
- 主营：ELISA试剂盒、PCR试剂盒、生化试剂盒、人纤维胶凝蛋白3ELISAKit、科研试剂
- 主营：Elisa试剂盒、PCR试剂盒、PCR检测、人FCN2ELISA试剂盒、PCR检测试剂盒、核酸检测试剂盒、荧光定量检测试剂盒、荧光定量试剂盒、比色法检测试剂盒、生化试剂盒、比色法试剂盒、酶活性比色法检测试剂盒、酶活性检测试剂盒、微量法检测试剂盒、分光光度检测试剂盒、酶活分光光度试剂盒、ELISA试剂盒、ELISA检测、酶联免疫试剂盒、酶联免疫检测试剂盒、酶联免疫、细胞、抗体
- 主营：纤维胶凝蛋白3、elisa试剂盒
- 主营：elisa试剂盒、小鼠elisa试剂盒、大鼠elisa试剂盒、人elisa试剂盒、植物elisa试剂盒、鱼elisa试剂盒、猪elisa试剂盒、牛elisa试剂盒、鸡elisa试剂盒、兔elisa试剂盒、犬elisa试剂盒
- 主营：人转谷氨酰胺酶、试剂盒、信号调节激酶
- 主营：人纤维胶凝蛋白3、Elisa试剂盒、检测试剂盒
- 主营：人纤维胶凝蛋白2、elisa 试剂盒
- 主营：纤维胶凝蛋白3、elisa试剂盒
- 主营：纤维胶凝蛋白2、elisa试剂盒、pcr检测试剂盒
- 主营：纤维胶凝蛋白、试剂盒、ELISA试剂盒、ELISA检测试剂盒
- 主营：骨成型蛋白9、ELISA试剂盒、抗体
- 主营：纤维胶凝蛋白3试剂盒、elisa试剂盒、试剂盒、抗体
- 主营：ELISA试剂盒、生化检测试剂盒、PCR试剂盒、大鼠ELISA试剂盒、小鼠ELISA试剂盒、兔ELISA试剂盒、鸡ELISA试剂盒