Human Angiostatin

Updated: 2026-08-07

Overview

Human Vasostatin-1 is a 180-amino acid peptide derived from the N-terminal domain (amino acids 1-180) of calreticulin, a multifunctional endoplasmic reticulum protein. It was first identified for its ability to inhibit vascular endothelial cell proliferation, earning its name from 'vaso-' (vessel) and '-statin' (inhibitor). The peptide has since become a focus in angiogenesis research due to its role in modulating tumor blood supply. As a research chemical, Vasostatin-1 is typically produced via recombinant DNA technology or peptide synthesis. Its primary mechanism involves binding to endothelial cell surface receptors, disrupting VEGF signaling pathways. This makes it particularly valuable for studying pathological angiogenesis in cancer and ischemic diseases.

Physical and Chemical Properties

The peptide exhibits stability in neutral pH buffers but may degrade under repeated freeze-thaw cycles or prolonged exposure to temperatures above 4°C. Its isoelectric point (pI) is approximately 4.5 due to the acidic amino acid residues in its sequence. Analytical techniques like mass spectrometry typically show a single peak at ~20 kDa when properly folded. Vasostatin-1's biological activity depends on its tertiary structure, particularly the globular N-domain conformation. Reducing agents should be avoided during reconstitution as they may disrupt disulfide bonds critical for function. The lyophilized form remains stable for years when stored properly, while solutions are typically stable for 1-2 weeks at 4°C.

Main Applications

In B2B contexts, Vasostatin-1 is primarily supplied to pharmaceutical companies and academic labs for angiogenesis inhibition studies. It serves as a positive control in anti-cancer drug screening assays, particularly for compounds targeting tumor vasculature. Some researchers utilize it in combination therapies to enhance the efficacy of conventional chemotherapeutic agents. The peptide also finds application in cardiovascular research, where its vasoregulatory properties are studied in atherosclerosis and diabetic retinopathy models. Biotech companies may incorporate it into drug delivery systems targeting tumor microenvironments. Current Good Manufacturing Practice (cGMP)-grade versions are available for preclinical development.

Safety and Storage

As a research chemical, Vasostatin-1 requires handling with laboratory-grade personal protective equipment including gloves and safety goggles. Although not classified as acutely toxic, it should be treated as a potential irritant. Any spills should be contained with absorbent materials and disposed of as biological waste. For long-term storage, lyophilized peptides should be kept at -20°C in sealed containers with desiccant packs. Aliquotting reconstituted solutions minimizes freeze-thaw damage. Suppliers typically provide nitrogen-flushed vials to prevent oxidation during shipping. Stability studies suggest negligible degradation when stored properly for up to 3 years.

B2B Procurement Guide

When sourcing Vasostatin-1, buyers should prioritize suppliers who provide comprehensive analytical documentation, including HPLC purity certificates (>95% recommended) and mass spectrometry verification. Bulk purchasers (gram quantities) may negotiate 15-30% discounts but should validate scale-up consistency through pilot testing. Lead times vary from 2-8 weeks depending on synthesis method and quality grade. Some suppliers offer custom modifications (e.g., fluorescent labeling or PEGylation) for specialized applications. Payment terms for institutional buyers often include net-30 options, while new customers may need to prepay. Cold chain shipping with dry ice is standard for international orders.