Overview
Hesperidin Methyl Chalcone (HMC) is a semi-synthetic flavonoid derived from hesperidin, a natural compound found in citrus fruits. It is widely used in the pharmaceutical and cosmetic industries due to its potent antioxidant and vasoprotective properties. HMC enhances microcirculation, reduces inflammation, and strengthens blood vessels, making it a popular ingredient in skincare products and dietary supplements. Research has shown that HMC can improve skin elasticity and reduce the appearance of dark circles under the eyes. Its ability to stabilize capillary walls and reduce permeability makes it effective in treating conditions like chronic venous insufficiency and hemorrhoids. The compound is typically available as a fine powder, soluble in water and ethanol, which facilitates its incorporation into various formulations.
Physical and Chemical Properties
Hesperidin Methyl Chalcone is a pale yellow to yellow crystalline powder with a molecular weight of 624.59 g/mol. It has a melting point range of 150-155°C and is soluble in water and ethanol, which enhances its versatility in formulation. The compound's stability under normal storage conditions makes it suitable for long-term use in industrial applications. The molecular structure of HMC includes a chalcone moiety, which contributes to its strong antioxidant activity. This structure allows it to scavenge free radicals and protect cells from oxidative stress. The compound's solubility profile and stability in various pH ranges make it ideal for use in both aqueous and alcoholic solutions, broadening its application scope.
Main Applications
Hesperidin Methyl Chalcone is primarily used in the pharmaceutical and cosmetic industries. In pharmaceuticals, it is incorporated into formulations for treating vascular disorders, such as chronic venous insufficiency and hemorrhoids, due to its vasoprotective and anti-inflammatory effects. It is also used in dietary supplements aimed at improving circulation and reducing oxidative stress. In cosmetics, HMC is valued for its ability to enhance skin microcirculation, reduce puffiness, and lighten dark circles under the eyes. It is commonly found in anti-aging creams, serums, and eye gels. The compound's antioxidant properties help protect the skin from environmental damage, making it a key ingredient in many skincare products targeting mature or sensitive skin.
Safety and Storage
Hesperidin Methyl Chalcone is generally recognized as safe (GRAS) when used in accordance with recommended guidelines. However, it is important to handle the compound with care to avoid inhalation or direct contact with eyes, as it may cause irritation. Proper personal protective equipment (PPE), such as gloves and masks, should be worn during handling. Storage conditions for HMC include keeping the compound in a cool, dry place away from light and moisture to maintain its stability and efficacy. Bulk quantities should be stored in tightly sealed containers to prevent contamination and degradation. Shelf life typically ranges from two to three years when stored under optimal conditions.
B2B Procurement Guide
When procuring Hesperidin Methyl Chalcone, it is essential to verify the CAS number (24292-52-2) and purity specifications to ensure product authenticity. Request certificates of analysis (COA) from suppliers to confirm the compound's quality and compliance with industry standards. Price ranges vary depending on purity and supplier, with typical costs between $50 and $150 per kg. Bulk buyers should establish relationships with reputable suppliers who can provide consistent quality and reliable delivery schedules. Consider conducting small-scale trials before large purchases to evaluate the product's performance in specific applications. Packaging options, such as sealed bags or drums, should be chosen based on storage and handling requirements.
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