Overview
Heraclenol is a naturally occurring coumarin derivative primarily extracted from plants of the Heracleum genus, such as Heracleum sphondylium. It belongs to the class of bioactive phytochemicals known for their diverse pharmacological effects, including anti-inflammatory, antioxidant, and potential anticancer properties. Coumarins like heraclenol are valued in both traditional medicine and modern pharmaceutical research for their therapeutic potential. In recent years, heraclenol has gained attention for its role in modulating cellular pathways linked to oxidative stress and inflammation. Its structural similarity to other coumarins allows it to interact with enzymes and receptors, making it a candidate for drug development. However, commercial availability remains limited, and it is primarily sourced for research purposes.
Physical and Chemical Properties
Heraclenol is characterized by its pale yellow crystalline appearance and a molecular weight of 258.27 g/mol. Its molecular formula, C15H14O4, reflects its coumarin backbone with additional functional groups that contribute to its bioactivity. The compound typically melts at 160-165°C, though precise data may vary depending on purity and crystalline form. Solubility is a critical factor for its application; heraclenol dissolves well in polar organic solvents like ethanol and dimethyl sulfoxide (DMSO) but has limited solubility in water. This property influences its formulation in lab settings, where it is often dissolved in DMSO for biological assays. Stability under standard storage conditions (cool, dry, and protected from light) ensures its longevity for research use.
Main Applications
The primary application of heraclenol lies in pharmaceutical and nutraceutical research. Its anti-inflammatory properties have been studied in preclinical models, suggesting potential use in treating chronic inflammatory conditions. Additionally, its antioxidant activity makes it a candidate for combating oxidative stress-related diseases, such as neurodegenerative disorders. Beyond therapeutics, heraclenol is explored in cosmetic formulations for its skin-protective effects. Some studies indicate it may inhibit tyrosinase, an enzyme involved in melanin production, which could lead to applications in brightening skincare products. However, commercial adoption is still in early stages, and further clinical validation is needed.
Safety and Storage
While heraclenol is not classified as highly hazardous, standard laboratory precautions should be followed. Personal protective equipment (PPE), including gloves and safety goggles, is recommended to prevent skin or eye contact. Inhalation of dust should be avoided, and handling should occur in a well-ventilated area or fume hood. Storage conditions are straightforward: keep the compound in airtight containers, protected from light and moisture, at room temperature or below. Prolonged exposure to heat or humidity may degrade its quality. For long-term storage, consider refrigeration with desiccants to maintain stability.
B2B Procurement Guide
Procuring heraclenol requires careful attention to supplier reliability and product specifications. Given its niche status, buyers should prioritize suppliers with transparent quality control measures, such as certificates of analysis (CoA) detailing purity (e.g., ≥95% by HPLC). Batch-to-batch consistency is crucial for research reproducibility. Pricing varies significantly based on purity and quantity, with research-grade quantities typically ranging from $100-$300 per gram. Consider requesting small samples for initial testing before bulk purchases. Additionally, verify logistics support, as some suppliers may have limited international shipping options for controlled substances.
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