Overview
Hepatitis A Virus (HAV) is a member of the Picornaviridae family, responsible for hepatitis A, a globally prevalent liver infection. Unlike hepatitis B or C, HAV does not cause chronic disease but can lead to severe acute illness. The virus is primarily spread through ingestion of contaminated water or food, particularly in regions with poor sanitation. HAV infections are often asymptomatic in children but may cause jaundice, fatigue, and abdominal pain in adults. Outbreaks are common in crowded or unsanitary conditions, making it a significant public health concern. Vaccination and improved hygiene have drastically reduced incidence in developed countries.
Key Features
HAV is a non-enveloped, icosahedral virus with a single-stranded RNA genome, making it resistant to detergents and environmental degradation. Its stability allows it to survive for months in water or soil, facilitating transmission. The virus replicates in the liver and is excreted in feces during the incubation period. Diagnostically, HAV is identified via IgM antibody tests during acute infection or PCR for RNA detection. Its antigenic uniformity means one serotype exists worldwide, simplifying vaccine development. Inactivated and live-attenuated vaccines, such as Havrix and Vaqta, provide long-term immunity.
Application Areas
HAV research focuses on epidemiology, vaccine efficacy, and rapid diagnostics. Public health initiatives use surveillance data to target vaccination campaigns in endemic areas like parts of Africa, Asia, and Latin America. Pharmaceutical companies produce inactivated vaccines for global distribution. In B2B contexts, HAV antigens and antibodies are critical for ELISA test kits, while biotech firms supply recombinant proteins for vaccine development. Wastewater monitoring for HAV RNA also aids outbreak prediction, especially in high-risk communities.
Precautions
Prevention relies on vaccination, which is recommended for travelers to endemic regions and high-risk groups (e.g., healthcare workers). Post-exposure prophylaxis with immune globulin can prevent symptomatic infection if administered within two weeks. Food industries must enforce handwashing and avoid shellfish from contaminated waters. Labs handling HAV samples require biosafety level 2 (BSL-2) precautions due to potential aerosol transmission. Disinfection with bleach (1:100 dilution) is effective against the virus.
B2B Procurement Guide
For diagnostic kits, buyers should verify regulatory approvals (e.g., FDA, CE) and clinical sensitivity data. Bulk purchases of vaccines may require cold-chain logistics, as HAV vaccines are temperature-sensitive. Suppliers of viral antigens should provide certificates of analysis (CoA) detailing purity and endotoxin levels. Negotiate contracts with flexibility for emergency orders during outbreaks. For reference, bulk diagnostic reagents cost approximately $10–$50 per test, depending on volume.
Related Manufacturers
- 主营：脂蛋白、能受体、gla蛋白、磷脂酶、蛋白酶、酮戊二、p53诱导、样因子、大鼠iii、jo1抗体、p21蛋白、糖蛋白、大鼠肝、akt蛋白、磷酸酶、样蛋白、ca-mg-atp、双链dna、联蛋白、域蛋白、羟甲基、抗抗体、合成酶、前胶原、大鼠羧
- 主营：蛋白酶、蜗牛酶、心肌黄酶、抗甲型肝炎病毒IgG抗体、亮抑肽酶、淀粉酶、乳糖酶、亮抑酶肽、硫代辅酶、细胞溶解酶、果胶酶、肌酸激酶、纤维素酶、枯草杆菌、乙醇脱氢酶、木聚糖酶、氯化溶菌酶、脂氧素、葡球菌酶、羧化辅酶、尿素酶、氯化酵素
- 主营：采样拭子、检测取样管、平面口罩、病毒管、病毒采样管、KN95口罩、兽用采血管、负压引流袋、负压引流装置、微量采血管、末梢采血管、生物安全型尿沉渣、一次性吸引管、鼻氧管
- 主营：夹竹桃、异奥卡、香附酮、儿茶素、白鲜碱、管花苷、紫檀芪、木栓醇、豆甾醇、植酸锌、苏木素、泽泻醇、龙血素、黄柏酮、蚱蜢酮、防己碱、葫芦素、乌甲素、印楝素、厚朴酚、皂苷元、标准品、双黄酮、樱桃苷、芝麻素
- 主营：260号溶剂油、二甲硫基甲苯二铵、二乙基甲苯二铵、GITC病毒采样检测试剂、硅油、二月桂酸二丁基锡、丙二醇、甘油丙三醇、对甲苯磺酰氯、聚乙二醇、丙二醇丁醚、乙二醇丁醚、乙酯、二甲苯、硫酸镍、氯化镍、氯化锌、溶剂油120号/150号/200号、D系列溶剂油D40/D60/D80、环保溶剂油D100/D110/D130、磺化煤油、莫卡/橡胶硫化剂
- 主营：大鼠白介素、小鼠脂联素、表皮生长因子、ELISA试剂盒、细胞因子、重组蛋白
- 主营：igg抗体、糖蛋白、试剂盒、脂蛋白、人瘦素、粗纤维、猪睾酮、烯二酮、nad激酶、测试盒、牛瘦素、牛胆酸、原果胶、磷酸酶、犬肾素、含水量、人蛋白、甜菜碱、igm抗体、dna抗体、磷脂酶、大鼠超、犬叶酸、人胆酸、样受体
- 主营：Elisa试剂盒、PCR试剂盒、PCR检测、禽传染性法氏囊病毒、PCR检测试剂盒、核酸检测试剂盒、荧光定量检测试剂盒、荧光定量试剂盒、比色法检测试剂盒、生化试剂盒、比色法试剂盒、酶活性比色法检测试剂盒、酶活性检测试剂盒、微量法检测试剂盒、分光光度检测试剂盒、酶活分光光度试剂盒、ELISA试剂盒、ELISA检测、酶联免疫试剂盒、酶联免疫检测试剂盒、酶联免疫、细胞、抗体
- 主营：防爆气象站、气象监测仪、小型气象站、自动气象站、农业气象站、光伏气象站、便携式气象仪、气象传感器、交通能见度监测站、手持气象站、微型气象仪、负氧离子监测站、校园气象站、空气质量监测站、水质在线监测仪、水文监测站、GNSS位移监测站、虫情测报灯、孢子捕捉仪、高标准农田设备、土壤墒情监测站、iv测试仪、EL检测仪、松材线虫检测仪、水质监测站
- 主营：试剂盒、人25羟基维生素、人低氧诱导因子
- 主营：科研试剂盒、酶免试剂盒、elisa试剂盒、鸡乳头瘤病毒E6抗体、生化试剂盒、细胞、生物试剂、进口ELISA试剂盒、PCR试剂盒、生化测试盒
- 主营：防护服、椅脚轮、氙灯老化、测定仪、传感器、皮革耐折、落球回弹、测试仪、试验箱、耐磨仪、耐擦洗、检测仪、雾化仪、试验机、试验仪、刮擦仪、测试箱、风速仪、整鞋耐磨、对色灯箱、呼吸气密、医用口罩、智能仪器、拧压滚轮、床毯燃烧
- 主营：低浓度烟尘测试仪、热湿法紫外烟气分析仪、手持气体检测仪、生物毒性检测仪、大流量空气微生物采样、β射线烟尘直读检测仪、环境空气综合采样器、WBGT指数仪、水质自动采样器、大流量采样器、碳排放监测仪、红外CO分析仪、浓缩微生物采样器、深水洗井采样器、便携式水样抽滤器、烟气综合分析仪、红外CO2分析仪、恶臭气体检测仪、水质抽滤仪、红外烟气综合分析仪、紫外臭氧测定仪、便携式明渠流量计、颗粒物采样器
- 主营：检测方、钠尿肽、试剂盒、鸭肝炎病毒1型、同源物、ep300检测、结合蛋白、大鼠c-肽(、微球蛋白、抗胰蛋白酶、淋巴瘤因子、蛋白磷酸酶、死亡激动剂、核心域蛋白1、大鼠e选择素、大鼠janus激酶、激活蛋白激酶、大鼠ⅱ型胶原、大鼠ⅳ型胶原、大鼠klotho蛋白、细胞激活因子、大鼠ⅲ型胶原、大鼠nadh脱氢酶1、大鼠ⅵ型胶原α1、elisa 检测试剂盒
- 主营：试剂盒、elisa试剂盒、细胞、pcr试剂盒
- 主营：科研试剂盒、酶免试剂盒、elisa试剂盒、小鼠呼肠弧病毒、细胞、生物试剂、进口ELISA试剂盒、PCR试剂盒、生化测试盒