Overview
Hemofiltration products are advanced medical devices designed to replicate the kidney's filtration function extracorporeally. They are integral to continuous renal replacement therapy (CRRT) and treat conditions like acute kidney injury, sepsis, and fluid overload. Unlike hemodialysis, hemofiltration relies on convection rather than diffusion, allowing better clearance of middle-molecular-weight toxins. These systems consist of a blood filter (hollow-fiber membrane), tubing set, dialysate/replacement fluid pumps, and monitoring modules. Modern iterations incorporate user-friendly interfaces and safety alarms. Their adoption has grown in ICUs due to hemodynamic stability benefits for critically ill patients.
Structure and Working Principle
A hemofiltration system's core component is its semipermeable membrane filter, typically made of biocompatible polysulfone. Blood flows through hollow fibers while hydrostatic pressure drives plasma water and solutes across the membrane (ultrafiltration). Replacement fluid is infused to maintain electrolyte balance. The system includes arterial/venous lines, pressure sensors, and a heparin pump for anticoagulation. Some models integrate adsorption cartridges for cytokine removal. Continuous operation (24/7) is possible, with flow rates adjustable between 20–35 mL/kg/hr. Advanced systems automate fluid balance via gravimetric or volumetric control.
Key Features
High-flux membranes (30–50 kDa cutoff) enable efficient removal of inflammatory mediators like IL-6 in sepsis. Biocompatibility minimizes complement activation and thrombogenicity. Modular designs allow customization with SLED (sustained low-efficiency dialysis) or CVVHDF (continuous venovenous hemodiafiltration) modes. Safety features include air detectors, blood leak alarms, and pressure limits. Some systems offer integrated citrate anticoagulation. Portability is a growing focus, with compact units weighing <20 kg for bedside use. Energy-efficient designs reduce hospital infrastructure demands.
Application Areas
Primary use is in ICUs for acute kidney injury (AKI), especially in multiorgan failure. CRRT is preferred over intermittent dialysis for hemodynamically unstable patients. Sepsis-associated AKI benefits from cytokine clearance. Cardiac surgery units employ hemofiltration for fluid management post-bypass. Chronic applications include hybrid therapies for end-stage renal disease patients intolerant to conventional dialysis. Emerging uses involve poisonings (e.g., lithium) and autoimmune disorders. Pediatric-specific systems address neonatal metabolic crises. Research explores combined liver-kidney support systems.
Maintenance and Precautions
Daily checks include membrane integrity tests and circuit patency assessments. Disposable filters require replacement every 24–72 hours to prevent biofilm formation. System disinfection follows manufacturer protocols, often using peracetic acid or heat. Anticoagulation (unfractionated heparin or regional citrate) demands frequent ACT/aPTT monitoring. Staff training should cover alarm troubleshooting and emergency circuit disconnection. Water quality must meet AAMI/ISO standards to avoid pyrogen reactions. Storage conditions typically require dry, room-temperature environments.
B2B Procurement Guide
Hospitals should evaluate throughput needs—high-volume centers may prefer multi-patient stations. Consumable costs (filters, fluids) often exceed capital expenses. Leasing options with upgrade paths suit budget-limited facilities. Verify regulatory compliance (FDA 510(k), CE Mark, MDR). Service contracts should cover 24/7 technical support. Compatibility with existing EMR systems streamlines documentation. Bulk purchases of disposables may attract 10–15% discounts. Pilot testing with short-term rentals is advisable before large-scale adoption.
Related Manufacturers
- 主营：医疗耗材批发
- 主营：强生超声刀头、巴德疝修补片、强生倒刺缝合线、血液过滤、疝修补补片、强生止血夹、强生止血纱、爱惜良缝合线、PDS缝合线、强生鱼骨线、磷酸锆钠银藻酸盐敷料、含银敷料、美必康、透析导管、长期透析导管、进口透析导管、巴德透析导管、组织胶水、百克钳、美皮康、保赫曼、神经导丝
- 主营：测试机、仪测试、检验机、测验仪、护目镜、卫生巾、astmf2992、测定机、耐磨仪、强力仪、nbs橡胶、织物胀、卫生纸、老化箱、检测仪、灼热丝、试验机、试验仪、纸尿裤、能检验、测定仪、呼吸气密、测试温度、口罩耳带、性测试仪
- 主营：骨密度仪、双能x线骨密度仪、超声骨密度仪、制氧机、AED除颤仪、麻醉机、电子血压计、微波治疗仪、心电监护仪、血糖仪、肺功能仪、眼科激光治疗仪、血氧仪、高分子夹板、血管鞘、急救包、喉镜、高压注射器、手术显微镜、听力筛查仪、视力筛查仪、呼吸机、牙科综合治疗台、临时起搏器、可视喉镜
- 主营：试剂盒、抗原检测试剂
- 主营：测试仪、检测仪器、试验仪、拉力机、耐碎石试验机、鲁尔圆锥测试仪
- 主营：鲁尔接头综合性能测试仪、热敷贴温度特性测试仪、偏光应力仪、血液滤过器检测、注射器滑动性能测试仪、自动瓶盖扭矩仪、玻璃瓶耐内压测试仪、耐碱性试验装置、鼻氧管综合性能测试仪、呼吸管路气流阻力测试仪、人工血管水渗透性测试仪、输液港多次穿刺测试仪、器身密合性正压测试仪、药液过滤器细菌截留性能测试仪、吸收速度测试仪、可分散性测试仪、导管动力注射流量与压力测试仪、玻璃瓶切割机、开启力测试仪、罐盖轴向承压力测试仪、内涂膜完整性测试仪
- 主营：防护服、测试机、模切机、开合盖、撕裂仪、热熔胶、络筒机、保护膜、pcb耐折、测量仪、拉力仪、霰弹袋、触摸屏、铅笔芯、气流仪、冷冻箱、测定仪、小样机、贴合机、力测试、光源箱、划圆机、刮划机、纸环压、水凝胶涂布机
- 主营：鲁尔接头综合性能测试仪、偏光应力仪、玻璃瓶耐热冲击试验机、血液透析器综合性能测试仪、玻璃瓶热震性试验机、玻璃瓶耐内压力测试仪、内涂层连续性测试仪、耐碱性实验装置、鼻氧管测试仪、热敷贴温度特性测试仪、高压注射器密合性测试仪、导管动力注射流量与压力测试仪、呼吸管路气流阻力测试仪、薄膜加压破裂强度测试仪、球囊偏心度测试仪、人工血管水渗透性测试仪、缝合线线径测量仪、闭合力传递系数测试仪、输液港多次穿刺测试仪、注射器滑动性能测试仪、器身密合性正压测试仪
- 主营：测试仪、试验机、测定仪、合成血液、试验仪、卫生纸球、性检测仪、手表佩戴、呼吸阻力、撕破强力、线径测量仪、织物强力机、湿态微生物、缝合针针尖、手表耐划伤、手套抗切割、法颗粒过滤、手术刀装配、弹力检测仪、防护服静电、细菌过滤效率、手术刀片锋利、鲁尔圆锥接头、水平垂直燃烧、平面度实验仪
- 主营：血液滤过器产品优质、控制系统、完整性测试仪、细菌截留测试仪
- 主营：分析仪、阻菌仪、马弗炉、血液滤过器测试仪属性、磨擦仪、测量仪、穿刺器、测硫仪、灭火剂、测汞仪、螺旋夹、匀胶机、润滑油、导热仪、挺度仪、安全帽、采血袋、轮椅车、真空泵、吸气阀、眼睛头、白度仪、润滑剂、缝合针、打火机、粘度计
- 主营：肺功能仪、蛇牌手术器械、听力检测设备、血液透析机、视力筛查仪、精神压力分析仪、动脉硬化检测仪
- 主营：骨密度仪、辐射保暖台、激光治疗仪、纤维血液透析滤过器、超声刀、呼吸机、心肺复苏机、监护仪、血气分析仪、彩色超声诊断仪、活检针
- 主营：偏光应力仪、呼吸阻力测试仪、超滤率测试仪、血液透析器综合性能测试仪、清除率测试仪、氦气检漏仪、孔径测试仪、完整性测试仪
- 主营：筛选仪、血压计、彩超、血液透析设备、监护仪、中耳分析仪、性功能治疗仪、睡眠监测仪、冲击波治疗仪、眼科设备、理疗仪、骨密度仪、心肺复苏机、检验设备、除颤仪、阴道镜、呼吸机、血气分析仪、麻醉机、同视机、病床、冲击波、视力筛查仪、三类注射泵、血氧仪、眼压计