Overview
Guaiazulene is a naturally occurring azulene derivative isolated from guaiac wood oil or chamomile. Its vivid blue color and therapeutic properties make it valuable in medical and cosmetic formulations. Initially identified for its anti-inflammatory effects, it is now synthesized for scalable industrial use. As a non-toxic compound, guaiazulene is favored in sensitive applications like pediatric or dermatological products. Its stability and compatibility with other ingredients further enhance its utility in multicomponent systems.
Physical and Chemical Properties
Guaiazulene crystallizes as blue needles with a distinctive aromatic odor. Its low melting point (31–33°C) allows easy incorporation into lipid-based formulations. The compound’s conjugated double-bond system contributes to its color and reactivity. Chemically, it resists hydrolysis but may degrade under prolonged UV exposure or strong oxidizers. Solubility in fats and organic solvents facilitates its use in ointments and emulsions, while water insolubility requires emulsifiers for aqueous systems.
Main Applications
In pharmaceuticals, guaiazulene is used in topical creams for burns, eczema, and post-surgical care due to its soothing and anti-inflammatory effects. Cosmetic formulations leverage its color and skin benefits in serums, masks, and aftersun products. Industrially, it serves as a dye for plastics and textiles. Recent research explores its potential in photodynamic therapy and as a marker in analytical chemistry.
Safety and Storage
While generally safe, guaiazulene may cause mild irritation in concentrated forms. Proper storage in amber glass containers under inert gas prevents oxidation. Bulk quantities should be kept below 25°C with humidity control. Regulatory status varies by region: It is approved for cosmetics in the EU (EC No. 1223/2009) but requires concentration limits (e.g., ≤0.1% in leave-on products). Always consult SDS for handling protocols.
B2B Procurement Guide
Procure guaiazulene from suppliers with ISO 9001 certification orGMP compliance for pharmaceutical grades. Key specifications include purity (HPLC ≥98%), heavy metal content (<10 ppm), and residual solvent levels. For cosmetics, opt for allergen-free versions. Pricing depends on order volume; contracts with quarterly deliveries often secure discounts. Sample testing for color consistency and stability is recommended before large purchases.
Related Manufacturers
- 主营：架桥剂、YW100 锂萃取剂、端羧基液体丁腈橡胶、薁磺酸钠、10-羟基癸酸、苯乙烯磷酸、肉豆蔻酸镁、硬脂酸钴、全氟三丁胺、乙烯基磷酸二乙酯、磷酸锰铁锂、β-磷酸三钙、十一烯酸、钨酸铝、1-乙炔基环已醇、间二异丙苯、锂硅合金、溴甲酚绿、生物活性玻璃、溴代海因树脂颗粒、红铝、龙涎酮、原丁酸三甲酯
- 主营：全氟聚醚二醇、全氟三丁胺、聚硅氮烷、愈创木薁磺酸钠、特种硅油、特种硅树脂
- 主营：甘氨酸、甘氨酰、阻燃剂、愈创木薁磺酸钠、甲醇钠、蒽甲酯、十八酸、溴壬烷、肉桂醇、葱油醇、肉桂醛、异丁酯、赖氨酸、叔丁醇、多佐胺、醛试剂、醇酯-12、乙氧基、脯氨酸、牛胆粉、癸酸酯、化合物、氟苯基、敏材料、氨酰胺、扁油酸
- 主营：乙酸龙脑酯、聚苯乙烯磺酸钠、乙基黄原酸钾、愈创木薁磺酸钠、2-十一酮
- 主营：5-三甲基己醛、正癸酸、樊多B醛、愈创木薁磺酸钠、聚乙二醇甲醚甲基丙烯酸酯、山梨醇缩水甘油醚、聚苯胺、磷脂酸铵盐、谷胱甘肽、二氧化钒、三羟甲基氨基甲烷盐酸盐、3二羟基萘、二苯酮、庚酰氯、菲尼酮、茶香醇、苹果酸、菠萝醚
- 主营：溴代吡咯腈、芥酸、异山梨醇、愈创木薁磺酸钠、异山梨醇二甲醚、四氯苯醌、对氨基苯乙酸、四乙酰核糖、对氨基苯甲酸、2,6-二氟苯胺、蒽醌
- 主营：减磨剂、防锈剂、添加剂、润滑剂、抗腐剂、丙烯酸、抗氧剂、改进剂、清净剂、极压剂、色墨油墨、金属钝化剂、无灰分散剂、聚氨酯乳液、聚氨酯树脂、复合油墨树脂、高分子化合物、润滑脂拉丝剂、润滑油破乳剂、膜强度增强剂、润滑油增稠剂、润滑脂增粘剂、导热油复合剂、硫化烷基酚钙、活塞环释放剂
- 主营：肉桂醛、肉桂酸、汉防己甲素、愈创木薁磺酸钠、阻燃剂、褪黑素、甘氨酸、增塑剂
- 主营：丁烯酯、甘氨酸、甲酸镍、木香油、乙酸镁、阻燃剂、乙酸镉、酸性橙、西瓜酮、硫酸锌、硫酸锆、硫酸锂、杨梅酯、百里酚、硫酸锶、硫酸锰、二苯胍、十八酸、紫苏葶、聚合物、肌氨酸、卡必醇、碳酸镧、褪黑素、磷酸铁
- 主营：凉味剂、聚苯胺、氨基多糖季胺盐、愈创木薁磺酸钠、五溴甲苯、2-氟丙烯酸甲酯、巯基丁醇、全氟三丁胺、酒石酸钾、硫代水杨酸
- 主营：愈创木薁磺酸钠、化妆品原料、各种表面活性剂、纺织用化学原料
- 主营：愈创木薁磺酸钠、香精香料、有机中间体、化工助剂
- 主营：愈创木薁磺酸钠、生物化工试剂、中间体、帕罗韦德中间体
- 主营：氯化钠、除味剂、聚乙烯胺、愈创木薁磺酸钠、二羟醋酸、肌氨基酸、聚乙烯铵、米诺地尔、醋酸亚铁、一水肌酸、树苔浸膏、2-丁二醇、纳米勃姆石、花椒油树脂、醋酸氯己定、糊状叶绿素、无味子醇甲、三硬脂酸铝、聚乙烯亚胺、胡椒基丁醚、全氟三丁胺、5-甲氧基色胺、聚酰亚胺树脂、人造康酿克油、有机硅季铵盐、氯化十六吡啶
- 主营：水杨甙、甘氨酸、水苏糖、愈创木薁磺酸钠厂家、乳酶生、阻燃剂、鳕鱼粉、西瓜酮、喹烯酮、硫酸锆、甲醇钾、虫胶酸、硫酸锶、紫苏葶、苯丁锡、红桔油、肌氨酸、四氢萘、布洛芬、嘧菌酯、碳酸镧、氟草隆、烟酰胺、磷酸铁、丙酸铵、碳酸镁