Overview
Sodium Hyaluronate (HA-Na) is the sodium salt of hyaluronic acid, a glycosaminoglycan naturally found in connective tissues, skin, and synovial fluid. It is renowned for its exceptional ability to retain moisture, binding up to 1,000 times its weight in water. This property makes it invaluable in skincare, medical, and pharmaceutical industries. Produced via bacterial fermentation or extraction from animal tissues, HA-Na is biodegradable and biocompatible. Its molecular weight varies, influencing its viscosity and applications—low molecular weight penetrates skin deeply, while high molecular weight forms protective films.
Physical and Chemical Properties
Sodium Hyaluronate is a white, odorless powder that dissolves readily in water, forming viscous solutions. Its viscosity depends on concentration, molecular weight, and temperature. Unlike hyaluronic acid, its sodium salt form offers better stability and solubility in formulations. The compound is highly hygroscopic and shear-thinning, meaning its viscosity decreases under stress (e.g., during injection). It degrades enzymatically via hyaluronidases or through oxidative reactions, with a half-life of hours to days in vivo. Its pH in solution is neutral (6–8), compatible with most cosmetic and pharmaceutical systems.
Main Applications
In cosmetics, HA-Na is a star ingredient in moisturizers, serums, and anti-aging products due to its hydrating and plumping effects. It improves skin elasticity and reduces wrinkles. In medicine, it’s used in ophthalmic surgeries (as a viscoelastic agent), joint injections (for osteoarthritis), and wound dressings (to promote healing). The pharmaceutical industry employs HA-Na in drug delivery systems for its controlled-release properties. Its biocompatibility also makes it ideal for dermal fillers and tissue engineering scaffolds. Emerging uses include nutraceuticals for joint health and veterinary applications.
Safety and Storage
Sodium Hyaluronate is non-toxic and non-irritating, classified as Generally Recognized as Safe (GRAS) by the FDA for topical and injectable use. However, powder forms can cause respiratory irritation if inhaled; handling with masks is advised. Storage requires protection from humidity (use desiccants) and temperatures below 25°C. Solutions are prone to microbial growth; preservatives like parabens or phenoxyethanol are often added. Sterile-grade HA-Na for medical use must meet strict endotoxin limits (<0.5 EU/mg).
B2B Procurement Guide
When procuring HA-Na, specify molecular weight (e.g., 50 kDa for penetration, 1,000 kDa for film-forming). Purity should exceed 95%, with certificates for heavy metals, microbial counts, and endotoxins. For cosmetics, opt for non-animal-derived (fermented) grades to align with vegan standards. Suppliers should provide technical data sheets (TDS) and material safety data sheets (MSDS). Bulk pricing varies by quantity and grade—medical-grade commands premiums. Partner with GMP-certified manufacturers for consistent quality. Sample testing for viscosity and moisture content is recommended.
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