Glucuronic Acid Reference Standard

Updated: 2026-09-16

Overview

Glucuronic Acid Reference Standard is a highly purified form of D-glucuronic acid, primarily used in pharmaceutical and biochemical laboratories for analytical purposes. It serves as a benchmark in quality control testing, ensuring the accuracy and consistency of assays and research methodologies. The compound is essential for validating analytical methods, calibrating instruments, and conducting enzymatic studies. As a reference standard, it must meet stringent purity and stability criteria to ensure reliable results. Manufacturers and research institutions rely on this standard to comply with regulatory requirements, such as those set by pharmacopeias (USP, EP, etc.). Its role in drug metabolism studies, particularly in glucuronidation processes, further underscores its importance in pharmaceutical development.

Physical and Chemical Properties

Glucuronic Acid Reference Standard is characterized by its white to off-white crystalline powder appearance. It has a molecular weight of 194.14 g/mol and a molecular formula of C6H10O7. The compound is soluble in water and slightly soluble in ethanol, making it suitable for aqueous-based analytical applications. Its melting point ranges approximately between 160-165°C, with decomposition observed at higher temperatures. The compound’s stability is influenced by storage conditions, requiring protection from light, moisture, and extreme temperatures. High-purity grades (≥98%) are typically available to meet the stringent demands of reference standards, ensuring minimal interference in sensitive assays.

Main Applications

The primary application of Glucuronic Acid Reference Standard is in pharmaceutical quality control, where it is used to validate analytical methods for drug formulations and metabolites. It plays a critical role in HPLC, GC, and spectrophotometric analyses, ensuring accurate quantification of glucuronic acid in complex matrices. In biochemical research, the standard is employed to study glucuronidation, a key detoxification pathway in mammals. It is also used in enzymatic assays to measure the activity of glucuronosyltransferases, enzymes involved in drug metabolism. Additionally, the compound finds use in the food and cosmetic industries for testing and regulatory compliance.

Safety and Storage

Glucuronic Acid Reference Standard should be handled with care to avoid inhalation or skin contact. Appropriate personal protective equipment (PPE), such as gloves and lab coats, is recommended during use. In case of exposure, rinse affected areas with water and seek medical advice if necessary. Storage conditions are critical to maintaining the compound’s integrity. It should be kept in a cool, dry place at 2-8°C, protected from light and moisture. Sealed containers are preferred to prevent contamination and degradation. Proper labeling and segregation from incompatible substances are also advised to ensure safety and stability.

B2B Procurement Guide

When procuring Glucuronic Acid Reference Standard, B2B buyers should prioritize suppliers with a proven track record in high-purity chemical manufacturing. Key considerations include verifying the compound’s purity (typically ≥98%), batch-specific certificates of analysis (CoA), and compliance with pharmacopeial standards (e.g., USP, EP). Buyers should also evaluate supplier reliability, lead times, and packaging options to ensure the product’s integrity during transit. Bulk purchases may offer cost advantages, but storage capacity and shelf-life must be factored in. Additionally, consider suppliers who provide technical support and documentation to facilitate regulatory compliance and analytical validation.