Overview
Glucosyl-β-Cyclodextrin (Glu-β-CD) is a enzymatically modified derivative of β-cyclodextrin, where glucose moieties are attached to the cyclic oligosaccharide structure. This modification significantly improves water solubility compared to native β-cyclodextrin, while retaining its ability to form inclusion complexes with hydrophobic molecules. The compound is widely used as a functional excipient in pharmaceutical formulations to enhance the solubility and bioavailability of poorly water-soluble drugs. Its biocompatibility and mild taste also make it suitable for food and cosmetic applications, where it acts as a stabilizer and flavor enhancer.
Physical and Chemical Properties
Glucosyl-β-Cyclodextrin appears as a fine white powder with high hygroscopicity. Its glucosylation increases water solubility to >50 g/100 mL at 25°C, compared to just 1.85 g/100 mL for unmodified β-cyclodextrin. The compound maintains the characteristic toroidal shape of cyclodextrins, with a hydrophobic cavity and hydrophilic exterior. Thermal analysis shows decomposition starting around 260°C without a distinct melting point. The glucosylation sites are primarily at the C2, C3, and C6 positions of the glucose units, creating a random substitution pattern that prevents crystallization and enhances amorphous character. This structural modification also reduces hemolytic activity compared to parent β-cyclodextrin.
Main Applications
In pharmaceuticals, Glu-β-CD serves as a multifunctional excipient for drug formulations. It improves solubility of active pharmaceutical ingredients (APIs), enhances drug stability by protecting sensitive compounds from degradation, and can mask unpleasant tastes. The food industry utilizes it as a natural flavor carrier and stabilizer for volatile compounds in products like beverages and dairy. The cosmetic industry employs Glu-β-CD for fragrance encapsulation in perfumes and personal care products, where it provides controlled release properties. Its mildness and non-irritating characteristics make it suitable for sensitive skin formulations. Emerging applications include use in analytical chemistry as a chiral selector in chromatography and as a green alternative to organic solvents in various industrial processes.
Safety and Storage
Glucosyl-β-Cyclodextrin has an excellent safety profile, with oral LD50 values in rats exceeding 5,000 mg/kg. It is generally recognized as safe (GRAS) for food use in many countries. However, as with all fine powders, inhalation should be avoided during handling to prevent respiratory irritation. For long-term storage, the material should be kept in airtight containers with desiccants to prevent moisture absorption. Bulk quantities are typically packaged in 25 kg fiber drums with polyethylene liners. Under proper conditions, the shelf life exceeds 3 years. Exposure to high humidity can cause caking but doesn't affect chemical stability. The powder is non-flammable and presents minimal environmental hazards.
B2B Procurement Guide
When sourcing Glucosyl-β-Cyclodextrin, buyers should prioritize suppliers with documented quality systems (GMP, ISO certification). Key specifications to verify include purity (typically ≥98%), residual solvent levels, and microbiological limits for pharmaceutical or food-grade material. Technical documents should provide detailed characterization including substitution degree (average number of glucose units per cyclodextrin molecule), typically ranging from 1-3. For specialized applications, some manufacturers offer custom substitution patterns. Large-volume buyers (100+ kg) can negotiate prices downward by 15-30%. Consider regional suppliers in China, Europe, and Japan, where most production capacity is concentrated. Lead times for custom orders average 4-6 weeks.
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