Overview
Glaucocalyxin B is a diterpenoid compound primarily isolated from Rabdosia japonica (蓝萼香茶菜), a herb used in traditional Chinese medicine. It belongs to the ent-kaurane class of natural products and has attracted scientific interest due to its demonstrated bioactivities, including anti-inflammatory, antibacterial, and anticancer effects. Recent studies highlight its potential in modulating signaling pathways like NF-κB, making it a candidate for drug development. As a specialized phytochemical, Glaucocalyxin B is typically supplied to pharmaceutical and academic research institutions. Its extraction process involves chromatographic techniques, contributing to its relatively high market price compared to bulk chemicals.
Physical and Chemical Properties
Glaucocalyxin B appears as a white crystalline solid with moderate solubility in organic solvents like dimethyl sulfoxide (DMSO) and methanol, but limited solubility in water. Its molecular structure features four rings characteristic of kaurane diterpenoids, with hydroxyl and carbonyl functional groups that influence its reactivity and interaction with biological targets. Thermal analysis shows stability up to 180°C, with decomposition occurring at higher temperatures. The compound exhibits optical activity due to chiral centers, requiring specific storage conditions to maintain purity. Analytical characterization typically employs HPLC-UV/ELSD and mass spectrometry for quality control.
Main Applications
In pharmaceutical research, Glaucocalyxin B is investigated for its ability to inhibit cancer cell proliferation, particularly in leukemia and breast cancer models. Studies suggest it induces apoptosis through mitochondrial pathways and shows synergistic effects with conventional chemotherapeutics. Its anti-inflammatory properties are being explored for autoimmune disease applications. Beyond therapeutics, the compound serves as a reference standard in phytochemical analysis and traditional medicine quality control. Some cosmetic research examines its potential as a natural active ingredient, though this remains exploratory. Current usage is predominantly in preclinical studies, with no approved drugs derived from it as of 2024.
Safety and Storage
As a bioactive compound, Glaucocalyxin B requires careful handling. Laboratory safety protocols mandate the use of nitrile gloves, safety goggles, and fume hoods during weighing and solution preparation. Although not classified as acutely toxic, prolonged exposure may cause irritation, and material safety data sheets (MSDS) should always be consulted. For long-term storage, aliquoting in amber vials under inert gas (argon/nitrogen) at -20°C is recommended to prevent oxidation. Solutions in DMSO should be used within 3 months when stored frozen. Facilities should maintain spill kits with absorbent materials suitable for organic compounds.
B2B Procurement Guide
When sourcing Glaucocalyxin B, buyers should prioritize suppliers that provide comprehensive certificates of analysis (COA) including HPLC purity (≥98%), residual solvent data, and chiral purity verification. Minimum order quantities often range from 10mg to 1g for research-grade material, with lead times of 2-4 weeks due to custom purification needs. Key procurement considerations include cold chain logistics for international shipments (preferably with temperature monitoring), supplier GMP compliance for preclinical studies, and batch-to-batch consistency documentation. Negotiating sample testing before bulk purchase is advisable given the compound's high cost. Emerging suppliers in China may offer competitive pricing but require rigorous quality audits.
Related Manufacturers
- 主营：蓝萼乙素、对照品、标准品
- 主营：中间体、天然产物、植物提取物、功能性原料、稀有人参皂苷、淫羊藿、橄榄苦苷、定制、研发、生产
- 主营：对照品、标准品、三叶苷、蓝萼乙素、姜烯酚、人参皂苷、地黄苷、科研试剂、实验室自制、生育三烯酚
- 主营：对照品、标准品、三叶苷、蓝萼乙素、姜烯酚、人参皂苷、地黄苷、科研试剂、实验室自制、高纯度植物单体、生育三烯酚
- 主营：精萃宝对照品、一叶萩碱、三叶豆紫檀苷、羟基红花黄色素A、苍术素、苍术酮、盐酸血根碱、盐酸白屈菜红碱、药根碱、藁本内酯、欧当归内酯A、高丽槐素、松果菊苷、马钱苷、莫诺苷
- 主营：钩藤碱、丹皮酚、c17h26o10、蓝萼乙素、高良姜、丹参酮、鞣花酸、川楝素、苍术素、芦竹碱、管花苷、苦参碱、土贝母、柚皮素、白麻苷、甜菜碱、紫草素、络石苷、木皂苷、苏木素、甘露糖、番茄碱、青蒿酸、皂苷rg2、芹菜素、紫杉醇
- 主营：吴茱萸、儿茶素、丹参酮、蓝萼乙素、石竹素、熊果酸、柚皮素、咖啡酸、刺蒺藜、柚皮苷、花青素、根皮素、橙皮素、葛根素、耙齿菌、芍药苷、甘草酸、浓缩粉、水杨苷、虎杖苷、根皮苷、栀子苷、利血平、西瓜粉、大黄苷、槐果碱
- 主营：对照品、科研实验、试剂盒、蓝萼乙素、多糖、安石榴苷、儿茶素、绿原酸、尿石素、人参皂苷、花青素、维生素、异鼠李素、甘草系列、人参系列、补骨脂系列、雷公藤系列、黄芩系列、柴胡系列、丹参系列、酸枣仁系列、重楼系列、大黄系列、五味子系列、化合物、黄芪皂苷系列
- 主营：异常山乙素、酒渣碱、芦丁标准品、对照品标准品
- 主营：标准品、细辛脂素、百两金素、延胡索乙素、桃叶珊瑚苷、脱氢紫堇碱
- 主营：氧化小檗碱、氧化石蒜碱、棉酚、蓝萼乙素、1-脱氧野尻霉素、花椒毒酚、4-去甲基鬼臼毒素、杨芽黄素、圣草酚、秦皮素、瑞香素、五味子酚、甘草素、甘草苷、连翘苷
- 主营：蓝萼乙素、白僵菌素、薯蓣皂苷
- 主营：标准品、中药对照品、槲皮万寿菊素、蓝萼乙素、新绿原酸
- 主营：中药对照品
- 主营：桉油精、标准品、薄荷脑、蓝萼乙素、中药对照品、白花前胡丙素、白藜芦醇三甲醚