Glaucocalyxin A

Updated: 2026-09-11

Overview

Glaucocalyxin A is a natural diterpenoid compound isolated from plants such as Rabdosia japonica, a species used in traditional Chinese medicine. It belongs to the ent-kaurane class of diterpenes and is recognized for its bioactive potential. Research highlights its role in modulating cellular pathways, particularly in inflammation and apoptosis, making it a candidate for drug development. Initially identified for its cytotoxic properties, Glaucocalyxin A has since been studied for broader pharmacological applications, including antiviral and anticancer effects. Its mechanism of action often involves inhibition of NF-κB signaling, a key pathway in inflammatory responses.

Physical and Chemical Properties

Glaucocalyxin A is a crystalline solid with a molecular weight of 332.43 g/mol and a melting point around 180-185°C. Its molecular structure includes multiple oxygen-containing functional groups, contributing to its solubility in polar organic solvents like dimethyl sulfoxide (DMSO) and ethanol. However, it exhibits limited solubility in water, which influences its formulation for research or therapeutic use. The compound is sensitive to light and moisture, requiring storage under controlled conditions to maintain stability. Analytical techniques such as HPLC and mass spectrometry are commonly employed to assess its purity, which is critical for reproducible experimental results.

Main Applications

Glaucocalyxin A is primarily investigated in preclinical studies for its antitumor and anti-inflammatory properties. In oncology, it has shown promise in inducing apoptosis in cancer cell lines, including breast and liver cancers. Its ability to suppress pro-inflammatory cytokines makes it a potential candidate for treating chronic inflammatory diseases. Beyond pharmaceuticals, the compound is occasionally used as a reference standard in phytochemical research to quantify diterpenoid content in plant extracts. Its applications remain experimental, with no approved clinical uses to date.

Safety and Storage

As a research chemical, Glaucocalyxin A requires careful handling to minimize exposure. Personal protective equipment (PPE) such as gloves and lab coats is recommended. Inhalation of dust or direct skin contact should be avoided due to potential irritant effects. Long-term stability is achieved by storing the compound in airtight containers at 2-8°C, protected from light and humidity. Degradation products can form under improper storage, potentially altering bioactivity. Material Safety Data Sheets (MSDS) should be reviewed prior to use.

B2B Procurement Guide

When sourcing Glaucocalyxin A, prioritize suppliers with ISO-certified manufacturing facilities and documented quality control processes. Key procurement criteria include purity (typically ≥98%, verified by HPLC), batch-to-batch consistency, and availability of analytical certificates. Bulk purchases may require negotiation, as prices vary based on quantity and purity. For research institutions, smaller quantities (1-10 mg) are commonly available. Lead times can extend to several weeks due to specialized extraction and purification processes.