Overview
Gemcitabine is a nucleoside analog chemotherapeutic agent widely used in oncology. It was first synthesized in the 1980s and approved by the FDA in 1996 under the brand name Gemzar. The drug works by incorporating itself into DNA during replication, leading to chain termination and inhibition of cancer cell proliferation. Gemcitabine is particularly effective against solid tumors, making it a cornerstone in treating pancreatic, breast, and lung cancers. Its mechanism of action involves both direct DNA damage and indirect effects on cellular metabolism, providing a multi-faceted approach to cancer therapy.
Physical and Chemical Properties
Gemcitabine is a white to off-white crystalline powder with a molecular weight of 263.20 g/mol. It is soluble in water and slightly soluble in methanol, which facilitates its formulation for intravenous administration. The drug is stable under recommended storage conditions but degrades upon exposure to heat or light. The compound's nucleoside structure allows it to mimic natural nucleotides, enabling its incorporation into DNA. This property is central to its antineoplastic activity. The fluorine atoms in its structure enhance its metabolic stability, prolonging its therapeutic effects.
Main Applications
Gemcitabine is primarily used to treat pancreatic cancer, often in combination with other drugs like nab-paclitaxel. It is also effective against metastatic breast cancer, non-small cell lung cancer (NSCLC), and ovarian cancer. In some cases, it is used off-label for bladder and biliary tract cancers. The drug's versatility stems from its ability to target rapidly dividing cells. It is commonly administered intravenously in clinical settings, with dosing regimens tailored to the specific cancer type and patient tolerance. Ongoing research explores its potential in combination therapies and novel delivery systems.
Safety and Storage
Gemcitabine is a cytotoxic agent and must be handled with strict safety protocols. Healthcare workers should wear gloves, gowns, and eye protection to avoid exposure. Accidental contact can cause skin irritation or more severe health effects. Proper storage is critical to maintaining the drug's efficacy. It should be kept at 2-8°C in a dry, dark environment. Solutions prepared for infusion are stable for up to 24 hours at room temperature but should be used promptly to minimize degradation.
B2B Procurement Guide
When procuring gemcitabine, B2B buyers should prioritize suppliers with Good Manufacturing Practice (GMP) certification. Verify the product's Certificate of Analysis (CoA) to ensure purity, typically ≥98%. Bulk purchases may offer cost advantages, but storage capacity must align with the drug's shelf-life constraints. Consider logistical factors such as cold chain requirements and lead times. Establish long-term relationships with reputable manufacturers to ensure consistent quality and supply. Regulatory compliance, including import/export restrictions, should also be confirmed.
Related Manufacturers
- 主营：[]
- 主营：肌氨酸钠、硫化锰、V50偶氮二异丁脒盐酸盐、吉西他滨杂质6BETA胞苷、腰果酚缩水甘油醚、乙硫氮、二新癸酸二甲基锡、三硫代碳酸钠、PX-4MP、芥酸PKO、四氧化三锰
- 主营：苄基丙酮
- 主营：乙氧羰基、苯并氮杂、氮杂双环、亚氨基二、五甲基环、氨基二乙酸、四氟硼酸盐、三叔丁基膦、苄酯盐酸盐、4-异丙基吡啶、溴甲基环戊烷、2-溴-7-羟基萘
- 主营：吡咯酯、藜芦酮、麦芽酚、吉西他滨中间体T61、铃兰醛、吴茱萸碱、聚谷氨酸、3-吲哚甲醛、农药中间体、7-羟基香豆素、4-羟基香豆素、6-氰基-2-萘酚、5-甲氧基色胺、6-甲基香豆素、β-氯代苯乙烷
- 主营：亚索化学试剂、化学试剂、生物试剂、检测试剂、化学色谱纯试剂、光谱纯试剂、分析纯AR试剂、优级纯GR试剂、基准试剂、高纯电子级试剂、标准化学试剂、滴定分析试剂、实验室试剂、通用试剂
- 主营：硫代癸烷、化学试剂、总镍试剂、吉西他滨碱、棕榈酸甲酯、正辛酸甲酯、仲丁基氯化镁、正庚基溴化镁、仲丁基溴化镁、棕榈酸异丙酯
- 主营：硫酸汞、硝酸汞、雷尼镍、盐酸吉西他滨分析纯、二十烷、丁二酸、硫化银、正己醇、硫酸镉、铋酸钠、苯甲醇、硅酸钠、正辛酸、硫酸镁、磷钨酸、滑石粉、草酸锡、蓖麻油、椰子油、钒试剂、异辛醇
- 主营：四苯硼钠、轮环藤宁、3-甲氧基苯甲酸、盐酸吉西他滨中间体、3-二甲基巴比妥酸、对苯二甲醛、邻苯二甲醛、碳酰肼、阻聚剂701、六氟异丙醇、高效阻聚剂705、EDC盐酸盐、医药中间体、有机中间体
- 主营：壬二酸、乙蒜素、氨乙基、吉西他滨中间体T61、防腐剂、143487-47-2、三唑硫酮、羟基硅油、邻氯苯腈、二碳二酸、玫瑰精贝司、戊二烯二环、基三甲氧基、己二胺哌啶、苯基噻唑脲、基二苯甲烷、氯代异丙烷、甘油基氨基、6-二氯苯腈、3，4-二氟苯腈、椰油酰胺丙基、甲基丙烯酸六、色谱分析试剂、双六氟磷酸盐、甲基苯甲酰胺、邻氰基苯甲醛
- 主营：科研试剂、n-甲基吡咯烷酮
- 主营：生物素、马来酰亚胺、叶酸peg巯基、聚乙二醇马来、聚乙二醇叠氮
- 主营：中药对照品、药物杂质标准品、中药农产空白基质、盐酸吉西他滨杂质Ⅰ、分析标准品、药典标准溶液、标准物质、标准品、对照品
- 主营：化工原料、诺氟羧酸、精细化工产品、(r)-3-氨基丁醇、兰索拉唑氯化物、氯甲基氯磺酸酯
- 主营：硫磺粉末
- 主营：甲氧基聚乙二醇、氨基聚乙二醇、羧基聚乙二醇、吉西他滨、巯基聚乙二醇、羟基聚乙二醇、马来酰亚胺聚乙二醇、四臂聚乙二醇、荧光素聚乙二醇、叠氮聚乙二醇、硅烷聚乙二醇、炔基聚乙二醇、生物素聚乙二醇、丙烯酸酯聚乙二醇、活性脂聚乙二醇、Boc保护基团聚乙二醇、Fmoc保护基团聚乙二醇、生物素小分子PEG衍生物、甲氧基小分子PEG衍生物