Overview
Garcinone C is a naturally occurring xanthone derivative predominantly found in Garcinia mangostana (mangosteen) and related species. As a secondary metabolite, it contributes to the plant's defense mechanisms and has garnered scientific interest for its bioactive potential. First isolated in the 1980s, Garcinone C belongs to the prenylated xanthone class, characterized by its unique isoprenoid side chains. Its structural complexity underpins its interaction with biological targets, making it a candidate for drug discovery and functional food applications.
Physical and Chemical Properties
Garcinone C exhibits typical xanthone UV absorption maxima at 240-260 nm and 300-320 nm, useful for analytical identification. Its crystalline form is stable under dry conditions but may degrade upon prolonged exposure to heat or humidity. The compound's lipophilicity, attributed to its prenyl groups, influences its solubility profile. This property is critical for formulation development, particularly in enhancing bioavailability for therapeutic applications. Spectroscopic data (NMR, IR) are essential for purity verification in commercial batches.
Main Applications
In pharmaceutical research, Garcinone C demonstrates inhibitory effects on pro-inflammatory cytokines like TNF-α and IL-6, suggesting utility in chronic disease management. Ongoing studies explore its role in modulating oxidative stress pathways. The nutraceutical industry incorporates it into antioxidant blends, often standardized to 10-20% purity. Cosmetic formulations leverage its free radical-scavenging capacity for anti-aging serums, typically at 0.1-1% concentrations. Research-grade quantities are supplied to academic labs studying its mechanisms of action.
Safety and Storage
As a research chemical, Garcinone C requires handling in ventilated environments with nitrile gloves and safety goggles. Although low acute toxicity is reported, material safety data sheets (MSDS) should always be consulted. Long-term stability is ensured by argon-vacuum sealed packaging with desiccants. Aliquotting is recommended to minimize freeze-thaw cycles. Contamination risks increase when stored in aqueous solutions, where degradation may occur within weeks at room temperature.
B2B Procurement Guide
Bulk purchasers should prioritize suppliers with ISO 17025-accredited analytical capabilities. Key due diligence includes batch-specific COAs verifying identity (via qNMR) and contaminants (heavy metals, residual solvents). For cosmetic/nutraceutical use, ensure ingredient status complies with target market regulations (e.g., FDA GRAS, EU Novel Food). MOQ negotiations often apply for >100g orders, with discounts of 15-30% common. Sample testing through third-party labs (e.g., Eurofins) mitigates quality risks.
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